Klingman J, Chui H, Corgiat M, Perry J
Department of Neurology, University of Southern California School of Medicine, Los Angeles.
Arch Neurol. 1988 Jun;45(6):645-7. doi: 10.1001/archneur.1988.00520300065020.
A retrospective study was undertaken to identify potential risk factors for the development of progressive postpoliomyelitis muscular atrophy (PPMA). Patients with PPMA (n = 57) were compared with patients with a history of poliomyelitis but without a history of progressive weakness (n = 49). Patients who later developed PPMA had histories of more widespread acute paralysis, but relatively greater functional recovery. They were less disabled, and reported higher recent activity levels. Seventy-nine percent of the total variance between the PPMA and control groups could be accounted for by recovery alone (ie, severity minus disability). Functional recovery is generally attributed to reinnervation of sarcomeres by collateral sprouting from surviving lower motor neurons. Since degree of recovery predicts the risk of developing PPMA, our findings suggest that enlarged motor units may carry an increased susceptibility for dysfunction and/or degeneration.
开展了一项回顾性研究，以确定进展性脊髓灰质炎后肌肉萎缩（PPMA）发生的潜在风险因素。将PPMA患者（n = 57）与有脊髓灰质炎病史但无进行性肌无力病史的患者（n = 49）进行比较。后来发生PPMA的患者有更广泛急性瘫痪的病史，但功能恢复相对较好。他们的残疾程度较轻，且报告近期活动水平较高。PPMA组与对照组之间79%的总差异仅可由恢复情况（即严重程度减去残疾程度）来解释。功能恢复通常归因于存活的下运动神经元通过侧支发芽对肌节进行再支配。由于恢复程度可预测发生PPMA的风险，我们的研究结果表明，增大的运动单位可能对功能障碍和/或退变更易感。
