[The theory of pinocytosis. Factors determining the dynamics of pinocytosis in capillary endothelium].

Peculiarities of the mechanism and conditions of pinocytosis vesicules formation in capillary endothelium are considered in relation to: 1) the size of a protein cluster which is formed from plasma proteins on the endotheliocyte plasma membrane surface, and initiates a caveole formation; 2) the value of intracapillary hydrostatic pressure providing energetics of the caveole transition in the vesicula and its comming off. The bound parameters of vesicules formation are calculated in comparison with the well-known experimental data. It is suggested that in other types of endocytosis the initial phase of the process (caveoles formation) is also connected with absorption of the protein molecules on the plasma membrane and their clusterisation. A possible explanation is given to the fact of vesicles quantitative increase in endothelium in hypertension.