Sakagami M, Harada T, Sano M, Sakai S, Matsunaga T
Acta Otolaryngol. 1987 Mar-Apr;103(3-4):189-97.
In order to examine evidence of high activity of pinocytosis in capillaries of the stria vascularis, quantitative morphometry of pinocytotic vesicles was carried out ultrastructurally by the horseradish peroxidase (HRP) tracer method. In guinea pigs, there was a significant difference between the stria vascularis and spiral ligament in the number of vesicles per micron 2 (p less than 0.05) and labelled vesicles per micron 2 (p less than 0.001). In normotensive control rats, the number of labelled vesicles per micron 2 in capillaries of the stria vascularis was significantly greater (p less than 0.001) than that of the spiral ligament. Results of acute hypertensive and acute hypotensive experiments both indicated that enhanced permeable capillaries of the stria vascularis showed no significant increase in the number of pinocytotic vesicles per micron 2, but that they showed a more significant increase in the number of labelled vesicles per micron 2 than non-enhanced permeable capillaries of the stria vascularis (p less than 0.01) and capillaries of the spiral ligament (p less than 0.001). These findings provide ultrastructural confirmation of our previous studies (4, 8, 9) that pinocytosis contributes to the high permeability of capillaries of the stria vascularis under normal and experimental acute hypertensive and acute hypotensive conditions.
为了检测血管纹毛细血管中高活性胞饮作用的证据，采用辣根过氧化物酶（HRP）示踪法对胞饮小泡进行超微结构定量形态学分析。在豚鼠中，血管纹和螺旋韧带每平方微米的小泡数量（p<0.05）以及每平方微米标记小泡数量（p<0.001）存在显著差异。在正常血压对照大鼠中，血管纹毛细血管每平方微米标记小泡数量显著多于螺旋韧带（p<0.001）。急性高血压和急性低血压实验结果均表明，血管纹通透性增强的毛细血管每平方微米胞饮小泡数量无显著增加，但与血管纹通透性未增强的毛细血管（p<0.01）和螺旋韧带毛细血管（p<0.001）相比，其每平方微米标记小泡数量增加更为显著。这些发现为我们之前的研究（4, 8, 9）提供了超微结构证实，即在正常以及实验性急性高血压和急性低血压条件下，胞饮作用有助于血管纹毛细血管的高通透性。
