[Description of the kinetics of allosteric polymeric enzymes with 2 ligands based on the generalized Ising model].

The two-ligand model for allosteric regulation of complex polymeric enzymes is offered. Two types of cooperative interactions are observed--the cooperative transformations inside the promoter and interactions of promoters themselves--along with the direct interaction of two ligands inside each subunit. The solution of the model is given and its kinetic properties are discussed.