信号转导的变构机制。
Allosteric mechanisms of signal transduction.
作者信息
Changeux Jean-Pierre, Edelstein Stuart J
机构信息
Receptors and Cognition, Institut Pasteur, 75724 Paris Cedex 15, France.
出版信息
Science. 2005 Jun 3;308(5727):1424-8. doi: 10.1126/science.1108595.
PMID:15933191
Abstract
Forty years ago, a simple model of allosteric mechanisms (indirect interactions between distinct sites), used initially to explain feedback-inhibited enzymes, was presented by Monod, Wyman, and Changeux. We review the MWC theory and its applications for the understanding of signal transduction in biology, and also identify remaining issues that deserve theoretical and experimental substantiation.
摘要
四十年前，莫诺德、怀曼和尚热提出了一种简单的变构机制模型（不同位点之间的间接相互作用），该模型最初用于解释反馈抑制酶。我们回顾了MWC理论及其在理解生物学信号转导方面的应用，并确定了仍值得进行理论和实验证实的遗留问题。
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