Artal R, Doug N, Wu P, Sperling M A
Department of Obstetrics and Gynecology, University of Southern California School of Medicine.
Biol Neonate. 1988;53(3):121-5. doi: 10.1159/000242771.
Previous studies have demonstrated impaired perinatal adaptation of glucose homeostasis with inappropriately low levels of catecholamines and glucagon in newborn infants born to diabetic mothers. To investigate whether these neonatal changes are related to maternal metabolic control, we sequentially measured plasma glucose, catecholamines and glucagon in the neonatal period in 10 infants born to well-controlled mothers with class B diabetes mellitus after uncomplicated pregnancies. Good glycemic control in the mothers resulted in appropriate counterregulatory hormone responses in the neonatal period, similar to those described in infants born to normal mothers. The significant rise in plasma epinephrine and glucagon paralleled the establishment of euglycemia, further suggesting that these hormones are important for perinatal adaptation of glucose homeostasis.
先前的研究表明，患有糖尿病的母亲所生的新生儿，其围产期葡萄糖稳态适应性受损，儿茶酚胺和胰高血糖素水平异常低下。为了研究这些新生儿变化是否与母亲的代谢控制有关，我们对10名在妊娠过程顺利的B级糖尿病且血糖控制良好的母亲所生的婴儿，在新生儿期连续测量了血浆葡萄糖、儿茶酚胺和胰高血糖素。母亲良好的血糖控制导致新生儿期有适当的反调节激素反应，类似于正常母亲所生婴儿的情况。血浆肾上腺素和胰高血糖素的显著升高与正常血糖的建立平行，进一步表明这些激素对围产期葡萄糖稳态的适应性很重要。
