College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 1, Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.
J Nat Prod. 2021 Mar 26;84(3):857-864. doi: 10.1021/acs.jnatprod.0c01123. Epub 2021 Mar 11.
Two new dimeric selaginellins, diselaginellins C and D ( and ), a new unusual derivative, selapiginellin A (), a new selaginpulvilin U (), and a known derivative, diselaginellin A (), were isolated from (P. Beauv.) Spring. Among these compounds, selapiginellin A () is the first naturally occurring compound comprising an ether-linked dimer of a selaginellin and a selaginpulvilin. The absolute configurations of , , and were elucidated by spectroscopic data analyses. Compound was found to regulate mRNA expression of the low-density lipoprotein receptor (LDLR) gene and LDLR-related genes.
从卷柏 (P. Beauv.) Spring 中分离得到两个新的二聚体卷柏素 C 和 D（和），一个新的不寻常衍生物，selapiginellin A（），一个新的 selaginpulvilin U（）和一个已知的衍生物 diselaginellin A（）。在这些化合物中，selapiginellin A（）是第一个包含 selaginellin 和 selaginpulvilin 的醚键连接二聚体的天然存在的化合物。通过光谱数据分析阐明了，，和的绝对构型。发现化合物调节低密度脂蛋白受体 (LDLR) 基因和 LDLR 相关基因的 mRNA 表达。
