College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, P. R. China.
Planta Med. 2012 Mar;78(4):390-2. doi: 10.1055/s-0031-1298175. Epub 2012 Jan 23.
Five selaginellin derivatives, including two new selaginellins termed selaginellins M (1) and N (2), and three previously identified compounds, selaginellin (3), selaginellin A (4), and selaginellin C (5), were isolated from the Selaginella tamariscina (Beauv.) Spring plant. In addition, four known biflavonoids, namely neocryptomerin ( 6), hinokiflavone (7), pulvinatabiflavone (8), and 7''- O-methylamentoflavone (9), were also isolated. The structures of new compounds 1 and 2 were elucidated by spectroscopic analysis. The cytotoxic activity of compounds 1- 9 was evaluated against a small panel of human cancer cell lines, including U251 (human glioma cells), HeLa (human cervical carcinoma cells), and MCF-7 (human breast cancer cells). The two new selaginellins, selaginellins M (1) and N (2), showed medium activity against the human cancer cell lines.
从卷柏（Beauv.）Spring 植物中分离得到了 5 种卷柏素衍生物，包括 2 种新型卷柏素，即卷柏素 M（1）和 N（2），以及 3 种先前鉴定的化合物，即卷柏素（3）、卷柏素 A（4）和卷柏素 C（5）。此外，还分离得到了 4 种已知的双黄酮类化合物，即新隐黄素（6）、扁柏黄素（7）、大波斯菊黄素（8）和 7''-O-甲基amentoflavone（9）。新化合物 1 和 2 的结构通过光谱分析阐明。对化合物 1-9 对一组小型人类癌细胞系（包括 U251（人神经胶质瘤细胞）、HeLa（人宫颈癌细胞）和 MCF-7（人乳腺癌细胞））的细胞毒性活性进行了评估。两种新型的卷柏素，即卷柏素 M（1）和 N（2），对人癌细胞系显示出中等活性。
