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在医疗资源受限的情况下,针对腹膜恶性肿瘤的循证治疗策略:COVID-19 大流行。

Evidence-Based Strategies for the Treatment of Peritoneal Malignancies during Health Care Resource Restriction: The COVID-19 Pandemic.

机构信息

University Health Network, Toronto, ON M5G 1L7, Canada.

Division of Surgical Oncology, Department of Surgery, University of Toronto, Toronto, ON M5G 1L7, Canada.

出版信息

Curr Oncol. 2020 Dec 1;28(1):40-51. doi: 10.3390/curroncol28010006.

Abstract

The COVID-19 pandemic has put enormous pressure on hospital resources, and has affected all aspects of patient care. As operative volumes decrease, cancer surgeries must be triaged and prioritized with careful thought and attention to ensure maximal benefit for the maximum number of patients. Peritoneal malignancies present a unique challenge, as surgical management can be resource intensive, but patients have limited non-surgical treatment options. This review summarizes current data on outcomes and resource utilization to help inform decision-making and case prioritization in times of constrained health care resources. A rapid literature review was performed, examining surgical and non-surgical outcomes data for peritoneal malignancies. Narrative data synthesis was cross-referenced with relevant societal guidelines. Peritoneal malignancy surgeons and medical oncologists reviewed recommendations to establish a national perspective on case triage and mitigating treatment strategies. Triage of peritoneal malignancies during this time of restricted health care resource is nuanced and requires multidisciplinary discussion with consideration of individual patient factors. Prioritization should be given to patients where delay may compromise resectability of disease, and where alternative treatment options are lacking. Mitigating strategies such as systemic chemotherapy and/or surgical deferral may be utilized with close surveillance for disease stability or progression, which may affect surgical urgency. Unique hospital capacity, and ability to manage the complex post-operative course for these patients must also be considered to ensure patient and system needs are aligned.

摘要

COVID-19 大流行给医院资源带来了巨大压力,影响了患者护理的各个方面。随着手术量的减少,癌症手术必须经过仔细的考虑和权衡,以确保最大限度地为最多数患者带来获益。腹膜恶性肿瘤带来了独特的挑战,因为手术管理可能需要大量资源,但患者的非手术治疗选择有限。这篇综述总结了当前关于腹膜恶性肿瘤的结局和资源利用的数据,以帮助在医疗资源有限的情况下为决策和病例优先级提供信息。

我们进行了快速文献回顾,检查了腹膜恶性肿瘤的手术和非手术结局数据。对叙事数据进行了综合分析,并与相关的社会指南进行了交叉参考。腹膜恶性肿瘤外科医生和肿瘤内科医生审查了建议,以建立国家层面的病例分类和减轻治疗策略的观点。

在医疗资源受限的情况下对腹膜恶性肿瘤进行分类需要进行多学科讨论,并考虑患者的个体因素。对于那些延迟可能影响疾病可切除性的患者,以及那些缺乏替代治疗选择的患者,应优先考虑。可以采用全身化疗和/或手术延迟等缓解策略,并密切监测疾病的稳定性或进展情况,这可能会影响手术的紧迫性。还必须考虑到医院的独特能力,以及管理这些患者复杂的术后过程的能力,以确保患者和系统的需求一致。

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Laparoscopy in the coronavirus disease 2019 (COVID-19) era.2019冠状病毒病(COVID-19)时代的腹腔镜检查
Gynecol Surg. 2020;17(1):3. doi: 10.1186/s10397-020-01070-7. Epub 2020 May 14.
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Cancer guidelines during the COVID-19 pandemic.2019冠状病毒病大流行期间的癌症指南。
Lancet Oncol. 2020 May;21(5):629-630. doi: 10.1016/S1470-2045(20)30217-5. Epub 2020 Apr 2.
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Managing COVID-19 in Surgical Systems.外科系统中新型冠状病毒肺炎的管理
Ann Surg. 2020 Jul;272(1):e1-e2. doi: 10.1097/SLA.0000000000003923.

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