College of Food Science and Engineering, Northwest A&F University, Yangling, P. R. China.
Institute of Wolfberry Engineering Technology Research, Ningxia Academy of Agricultural and Forestry Sciences, Yinchuan, P. R. China.
Food Funct. 2021 May 11;12(9):3855-3871. doi: 10.1039/d0fo02936j.
A high-fat diet (HFD) promotes tissue inflammation, oxidative stress and insulin resistance (IR), thereby contributing to the development of obesity and diabetes. Anthocyanins from Lycium ruthenicum (AC) have demonstrated anti-obesity effects and modulated IR. To investigate the mechanism by which AC attenuates the adverse effects of consuming a HFD, C57BL/6J mice were fed a HFD supplemented with AC or a control diet without AC for 12 weeks. AC supplementation decreased the amount of weight gain, hepatic lipid, and sequentially improved dyslipidemia, inflammation, oxidative stress, and IR in HFD-fed mice. Molecular data revealed that AC inhibited hepatic inflammation by reducing TLR4/NF-κB/JNK in the liver tissues and ameliorated oxidative stress by activating the Nrf2/HO-1/NQO1 pathway. Thus, AC might activate IRS-1/AKT and prevent HFD-induced gluconeogenesis and IR by ameliorating inflammation and oxidative stress. Modulation of inflammation and oxidative stress with AC may represent a promising target for the treatment of IR and provide insight into the mechanism by which AC protects against obesity.
高脂肪饮食（HFD）可促进组织炎症、氧化应激和胰岛素抵抗（IR），从而导致肥胖和糖尿病的发生。黑果枸杞中的花色苷（AC）具有抗肥胖作用，并调节 IR。为了研究 AC 减轻 HFD 不良影响的机制，将 C57BL/6J 小鼠用补充 AC 的 HFD 或不含 AC 的对照饮食喂养 12 周。AC 补充可减少体重增加、肝脏脂质，并依次改善 HFD 喂养小鼠的血脂异常、炎症、氧化应激和 IR。分子数据显示，AC 通过减少肝脏组织中的 TLR4/NF-κB/JNK 来抑制肝炎症，并通过激活 Nrf2/HO-1/NQO1 通路来改善氧化应激。因此，AC 可能通过改善炎症和氧化应激来激活 IRS-1/AKT，并防止 HFD 诱导的糖异生和 IR。用 AC 调节炎症和氧化应激可能是治疗 IR 的有前途的靶点，并深入了解 AC 预防肥胖的机制。
