TCRLBCL 的免疫逃逸机制。
Immune escape mechanisms for TCRLBCL.
机构信息
City of Hope National Medical Center.
出版信息
Blood. 2021 Mar 11;137(10):1274-1276. doi: 10.1182/blood.2020008766.
Abstract
T-cell/histiocyte-rich large B-cell lymphoma (TCRLBCL) has a unique tumor microenvironment (TME) with an extensive infiltrate of T cells and histiocytes. In this issue of , Griffin et al found that the unique immunoarchitecture of this TME could be an important contributor to immune escape of the lymphoma cells.
摘要
T 细胞/组织细胞丰富型大 B 细胞淋巴瘤（TCRLBCL）具有独特的肿瘤微环境（TME），其中有大量的 T 细胞和组织细胞浸润。在本期 杂志中，Griffin 等人发现，这种 TME 的独特免疫结构可能是淋巴瘤细胞免疫逃逸的一个重要因素。
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2
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