TCRLBCL 的免疫逃逸机制。
Immune escape mechanisms for TCRLBCL.
机构信息
City of Hope National Medical Center.
出版信息
Blood. 2021 Mar 11;137(10):1274-1276. doi: 10.1182/blood.2020008766.
Abstract
T-cell/histiocyte-rich large B-cell lymphoma (TCRLBCL) has a unique tumor microenvironment (TME) with an extensive infiltrate of T cells and histiocytes. In this issue of , Griffin et al found that the unique immunoarchitecture of this TME could be an important contributor to immune escape of the lymphoma cells.
摘要
T 细胞/组织细胞丰富型大 B 细胞淋巴瘤（TCRLBCL）具有独特的肿瘤微环境（TME），其中有大量的 T 细胞和组织细胞浸润。在本期 杂志中，Griffin 等人发现，这种 TME 的独特免疫结构可能是淋巴瘤细胞免疫逃逸的一个重要因素。
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本文引用的文献
1
Spatial signatures identify immune escape via PD-1 as a defining feature of T-cell/histiocyte-rich large B-cell lymphoma.
Blood. 2021 Mar 11;137(10):1353-1364. doi: 10.1182/blood.2020006464.
2
A Probabilistic Classification Tool for Genetic Subtypes of Diffuse Large B Cell Lymphoma with Therapeutic Implications.
Cancer Cell. 2020 Apr 13;37(4):551-568.e14. doi: 10.1016/j.ccell.2020.03.015.
3
Genomic characterization of diffuse large B-cell lymphoma transformation of nodular lymphocyte-predominant Hodgkin lymphoma.
Leukemia. 2020 Aug;34(8):2238-2242. doi: 10.1038/s41375-020-0739-7. Epub 2020 Feb 13.
4
Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution.
Science. 2019 Mar 29;363(6434):1463-1467. doi: 10.1126/science.aaw1219. Epub 2019 Mar 28.
5
New tools for pathology: a user's review of a highly multiplexed method for in situ analysis of protein and RNA expression in tissue.
J Pathol. 2019 Apr;247(5):650-661. doi: 10.1002/path.5223. Epub 2019 Feb 20.
6
, , , and are frequently mutated in T-cell/histiocyte-rich large B-cell lymphoma.
Haematologica. 2019 Feb;104(2):330-337. doi: 10.3324/haematol.2018.203224. Epub 2018 Sep 13.
7
Profiling Tumor Infiltrating Immune Cells with CIBERSORT.
Methods Mol Biol. 2018;1711:243-259. doi: 10.1007/978-1-4939-7493-1_12.
8
Single-cell RNA sequencing: Technical advancements and biological applications.
Mol Aspects Med. 2018 Feb;59:36-46. doi: 10.1016/j.mam.2017.07.003. Epub 2017 Aug 1.
9
Single-cell mass cytometry for analysis of immune system functional states.
Curr Opin Immunol. 2013 Aug;25(4):484-94. doi: 10.1016/j.coi.2013.07.004. Epub 2013 Aug 31.
10
Cooperative epigenetic modulation by cancer amplicon genes.
Cancer Cell. 2010 Dec 14;18(6):590-605. doi: 10.1016/j.ccr.2010.11.013.
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