Department of Food Science and Biotechnology, Daegu University, Gyeongsan, Republic of Korea.
Plasma Technology Research Center, National Fusion Research Institute, Gunsan, Republic of Korea.
Biosci Biotechnol Biochem. 2021 Apr 24;85(5):1069-1076. doi: 10.1093/bbb/zbab020.
(-)-Epigallocatechin gallate (EGCG) and olivetol hybrid molecules 1-4 were conveniently synthesized using dielectric barrier discharge plasma irradiation. The structures of these unprecedented hybrid molecules were determined by interpretation of spectroscopic data. The unusual hybrid 1 showed improved antiglycation potency toward the advanced formation of glycation end products than the original EGCG and olivetol. The novel hybrid 1 is an interesting new class of antiglycation candidate that requires further investigation.
（-）-表没食子儿茶素没食子酸酯（EGCG）和橄榄苦苷混合分子 1-4 可通过介质阻挡放电等离子体辐照方便地合成。通过光谱数据的解释确定了这些前所未有的混合分子的结构。不寻常的混合分子 1 对糖基化终产物的高级形成表现出改善的抗糖化效力，优于原始 EGCG 和橄榄苦苷。新型混合分子 1 是一种有趣的新型抗糖化候选物，需要进一步研究。
