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围手术期感染新型冠状病毒肺炎的髋部骨折患者的死亡率

Mortality among hip fracture patients infected with COVID-19 perioperatively.

作者信息

Fessler Johannes, Jacobsen Thomas, Lauritzen Jes Bruun, Jørgensen Henrik Løvendahl

机构信息

Department of Orthopedic Surgery, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 KBH NV, Copenhagen, Denmark.

Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 KBH N, Copenhagen, Denmark.

出版信息

Eur J Trauma Emerg Surg. 2021 Jun;47(3):659-664. doi: 10.1007/s00068-021-01634-y. Epub 2021 Mar 11.

DOI:10.1007/s00068-021-01634-y
PMID:33704515
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7947941/
Abstract

BACKGROUND AND PURPOSE

The outbreak of the COVID-19 pandemic has resulted in an overall decline in fractures. However, the amount of hip fractures has remained relatively stable throughout the period. The objective of this study is to investigate the impact of perioperative COVID-19 infections on mortality among hip fracture patients.

METHODS

A meta-analysis was performed by collecting current data available through a systematic literature search in the PubMed database. The search was performed Oct 18 2020.

RESULTS

The meta-analysis was conducted on a trial population consisting of 1.272 hip fracture patients with a pooled prevalence of COVID-19 of 18%. Mortality among hip fracture patients without a perioperative COVID-19 infection was 7.49%. Mortality among hip fracture patients infected with COVID-19 perioperatively was associated with an odds ratio of 6.70 [(95% CI 4.64-9.68), p < 0.00001, I = 41%]. A sensitivity analysis showed no major impact of assumptions regarding varying definitions of COVID-19 statuses among the included studies.

CONCLUSION

Perioperative infections with COVID-19 in hip fracture patients are correlated with a significantly increased mortality. The meta-analysis showed a pooled odds ratio of 6.70 [(95% CI 4.64-9.68), p < 0.00001, I = 41%].

摘要

背景与目的

新型冠状病毒肺炎（COVID-19）大流行的爆发导致骨折总体发生率下降。然而，在此期间髋部骨折的数量一直相对稳定。本研究的目的是调查围手术期COVID-19感染对髋部骨折患者死亡率的影响。

方法

通过在PubMed数据库中进行系统文献检索收集现有数据进行荟萃分析。检索于2020年10月18日进行。

结果

对1272例髋部骨折患者的试验人群进行了荟萃分析，COVID-19的合并患病率为18%。围手术期无COVID-19感染的髋部骨折患者死亡率为7.49%。围手术期感染COVID-19的髋部骨折患者死亡率的比值比为6.70[（95%CI 4.64-9.68），p<0.00001，I=41%]。敏感性分析表明，纳入研究中关于COVID-19状态不同定义的假设没有重大影响。

结论

髋部骨折患者围手术期感染COVID-19与死亡率显著增加相关。荟萃分析显示合并比值比为6.70[（95%CI 4.64-9.68），p<0.00001，I=41%]。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5985/7947941/406854abe783/68_2021_1634_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5985/7947941/15f9e470ece4/68_2021_1634_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5985/7947941/bf97114f3183/68_2021_1634_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5985/7947941/675879aad08a/68_2021_1634_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5985/7947941/406854abe783/68_2021_1634_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5985/7947941/15f9e470ece4/68_2021_1634_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5985/7947941/bf97114f3183/68_2021_1634_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5985/7947941/675879aad08a/68_2021_1634_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5985/7947941/406854abe783/68_2021_1634_Fig4_HTML.jpg

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