Head and Neck Department, "Fondazione Policlinico Universitario A. Gemelli - IRCCS," School of Dentistry, Università Cattolica del Sacro Cuore, Largo A. Gemelli, 8, 00168, Rome, Italy.
Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.
Clin Oral Investig. 2021 Oct;25(10):5687-5697. doi: 10.1007/s00784-021-03870-3. Epub 2021 Mar 11.
The aim of this study was to evaluate the postoperative course in patients undergoing oral mucosal biopsies, considering clinical and patient's perception variables potentially correlated to poor healing.
Eighty patients underwent oral biopsies. All the variables connected with the surgery were recorded, and the harvested volume was calculated through image software (ImageJ, NIH, Betesda, USA). To evaluate the postoperative discomfort, the OHIP-14 and the numeric rating scale of pain (NRS) were administered at 6 h, 7 days and 21 days after biopsy.
Six hours after the biopsy, 22 (OHIP-14 ≥ 20) and 24 (NRS ≥ 4) patients experienced a troublesome or painful healing, respectively. A significant statistical correlation between poor healing and high scores of NRS and OHIP was detected (Pearson's correlation test p < 0.05). Higher values of OHIP-14 were correlated to the type of lesion (OR = 1.165; p < 0.05), whereas high values of NRS were correlated to the use of systemic drugs (p < 0.05). No surgical variable had a significant statistical correlation with any of the outcomes.
The clinical evaluation was correlated with the patient's perception of pain and discomfort. This finding could be suggestive of the fact that wound healing can be reliably monitored with the help of these tools.
Patient perception can be a predictor of the healing of biopsied tissues.
本研究旨在评估行口腔黏膜活检术患者的术后病程，考虑与愈合不良相关的临床和患者感知变量。
80 例患者接受了口腔活检。记录所有与手术相关的变量，并通过图像软件（ImageJ，NIH，美国贝塞斯达）计算采集的体积。为评估术后不适，在活检后 6 小时、7 天和 21 天分别采用 OHIP-14 和疼痛数字评分量表（NRS）进行评估。
活检后 6 小时，22 例（OHIP-14≥20）和 24 例（NRS≥4）患者的愈合出现麻烦或疼痛。NRS 和 OHIP 评分较高与愈合不良之间存在显著的统计学相关性（Pearson 相关检验 p<0.05）。OHIP-14 评分较高与病变类型相关（OR=1.165；p<0.05），而 NRS 评分较高与全身用药相关（p<0.05）。任何手术变量与任何结果均无显著统计学相关性。
临床评估与患者对疼痛和不适的感知相关。这一发现提示，这些工具可用于可靠监测活检组织的愈合情况。
患者感知可能是预测活检组织愈合的一个指标。
