Lai H
Department of Pharmacology, University of Washington School of Medicine, Seattle 98195.
Brain Res. 1988 Mar 1;442(2):403-6. doi: 10.1016/0006-8993(88)91535-1.
Acute (45 min) exposure to noise has been shown to decrease sodium-dependent high-affinity choline uptake activity in the frontal cortex and hippocampus of the rat. In the present experiment, the effects of repeated noise exposure on choline uptake in these two brain regions were studied. Rats were exposed to 100-dB white noise in ten 45-min sessions. Tolerance developed to the effects of noise on choline uptake. In addition, the effects were found to be classically conditionable to cues in the exposure environment. These data may have important implications in understanding the health hazard of noise exposure in both the public and occupational environments.
已有研究表明，急性（45分钟）噪声暴露会降低大鼠额叶皮质和海马体中钠依赖性高亲和力胆碱摄取活性。在本实验中，研究了重复噪声暴露对这两个脑区胆碱摄取的影响。将大鼠分十次、每次45分钟暴露于100分贝的白噪声中。机体对噪声影响胆碱摄取产生了耐受性。此外，还发现这些影响可通过经典条件作用与暴露环境中的线索相关联。这些数据对于理解公共和职业环境中噪声暴露的健康危害可能具有重要意义。
