Department of Medical Biochemistry, Faculty of Medicine, Bezmialem Vakif University, 34093, Istanbul, Turkey.
Department of Gynaecology and Obstetrics, Istanbul Education Research Hospital, 34098, Istanbul, Turkey.
Biol Trace Elem Res. 2022 Feb;200(2):464-472. doi: 10.1007/s12011-021-02660-y. Epub 2021 Mar 11.
Preeclampsia is one of the leading causes of maternal mortality-morbidity, and environmental factors act as the main driving force for the development of disease in genetically lean women. Trace element levels (zinc, copper) and thiol state (total, native thiol) may affect involved risk factors and play a role in the pathogenesis. The objective of our study is to assess trace element and thiol levels in patient and control groups. A total number of 88 pregnant women (in their third trimester) included 43 preeclampsia patients and 45 normotensive pregnant women as controls. The main findings of this study were the significantly elevated copper levels and decreased thiol levels (native and total thiols) in the patient group compared to controls (p < 0.05). Disulfide levels were not statistically different between the groups (p > 0.05). In patients, the predictive cutoff value of copper was 224 μg/dL and was 1.19 for the copper/native thiol ratio. Zinc levels were not statistically different between the two groups. Correlation analysis revealed no relationship between zinc-copper and zinc-total thiol levels in patients, while a positive correlation was evident in controls (zinc-copper, p < 0.05, r = 0.425, and zinc-total thiol levels, p < 0.05, r = 0.642). Patients had marginally high ALT and AST values in the normal range, and a significant difference was found between the two groups (p < 0.05). According to these results, elevated copper levels and decreased thiol levels may have a value for early prediction. The mechanisms that may be responsible for the altered element and thiol status have been discussed here in the context of oxidative stress.
子痫前期是孕产妇发病率和死亡率的主要原因之一，环境因素是导致瘦素基因女性发病的主要驱动因素。微量元素水平（锌、铜）和巯基状态（总巯基、天然巯基）可能影响相关危险因素，并在发病机制中发挥作用。我们研究的目的是评估患者组和对照组的微量元素和巯基水平。共有 88 名孕妇（孕晚期），其中 43 名子痫前期患者和 45 名正常血压孕妇作为对照组。本研究的主要发现是与对照组相比，患者组的铜水平显著升高，巯基水平（天然巯基和总巯基）降低（p<0.05）。两组之间的二硫键水平无统计学差异（p>0.05）。在患者中，铜的预测截断值为 224μg/dL，铜/天然巯基比值为 1.19。两组间锌水平无统计学差异。相关性分析显示，患者组的锌-铜和锌-总巯基水平之间无相关性，而对照组存在正相关性（锌-铜，p<0.05，r=0.425，锌-总巯基，p<0.05，r=0.642）。患者的 ALT 和 AST 值在正常范围内偏高，两组间有显著差异（p<0.05）。根据这些结果，铜水平升高和巯基水平降低可能对早期预测有价值。这里讨论了可能导致元素和巯基状态改变的机制，并在氧化应激的背景下进行了讨论。
