Kaya Başak, Turhan Uğur, Sezer Salim, Bestel Ayşegül, Okumuş Zihniye Gonca, Dağ İsmail, Erel Özcan
Department of Maternal-Fetal Medicine, Health Sciences University, Antalya Education and Research Hospital, Antalya, Turkey.
Department of Maternal-Fetal Medicine, Health Sciences University, Kanuni Sultan Süleyman Education and Research Hospital, İstanbul, Turkey.
J Matern Fetal Neonatal Med. 2020 Feb;33(4):671-676. doi: 10.1080/14767058.2018.1557140. Epub 2018 Dec 20.
To investigate thiol/disulfide homeostasis (TDH) and thioredoxin domain-containing 5 (TXNDC5) level in early and late-onset preeclampsia. In this cross-sectional study, 24 pregnant women with early-onset preeclampsia and 26 pregnant women with late-onset preeclampsia were compared with 30 pregnant women with no obstetric complications. The serum TXNDC5 levels and thiol/disulfide homeostasis were measured. Serum TXNDC5 levels were significantly higher in the early-onset and late-onset preeclampsia groups compared with the control group ( < .05). Native thiol and total thiol levels were significantly lower in the early-onset and late-onset preeclampsia groups than control group. The disulfide levels were found as significantly high in early preeclamptic patients compared to control group ( < .05). The highest levels of TXNDC5 and the lowest levels of native thiol and total thiol were found in early-onset preeclampsia group. No significant difference was found between the patients with early onset and late onset preeclampsia regarding TXNDC5 levels and thiol/disulfide homeostasis ( > .05). Serum TXNDC5 levels were significantly higher in patients with early-onset and late-onset preeclampsia. The dynamic thiol/disulfide homeostasis was impaired in favor of the oxidized state in patients with preeclampsia.
研究早发型和晚发型子痫前期患者的硫醇/二硫键稳态（TDH）及含硫氧还蛋白结构域5（TXNDC5）水平。在这项横断面研究中，将24例早发型子痫前期孕妇和26例晚发型子痫前期孕妇与30例无产科并发症的孕妇进行比较。检测血清TXNDC5水平及硫醇/二硫键稳态。早发型和晚发型子痫前期组的血清TXNDC5水平均显著高于对照组（<0.05）。早发型和晚发型子痫前期组的天然硫醇和总硫醇水平均显著低于对照组。与对照组相比，早发型子痫前期患者的二硫键水平显著升高（<0.05）。早发型子痫前期组TXNDC5水平最高，天然硫醇和总硫醇水平最低。早发型和晚发型子痫前期患者在TXNDC5水平及硫醇/二硫键稳态方面无显著差异（>0.05）。早发型和晚发型子痫前期患者的血清TXNDC5水平均显著升高。子痫前期患者的动态硫醇/二硫键稳态受损，有利于氧化状态。
