Dluzen D E, Laping N J, Ramirez V D
Department of Physiology and Biophysics, University of Illinois, Urbana 61801.
Brain Res. 1988 Apr 5;445(2):354-7. doi: 10.1016/0006-8993(88)91198-5.
The ability of superfused corpus striatal tissue fragments to release endogenous dopamine (DA) in response to potassium (K+ 30 mM) stimulation was significantly attenuated in 18- to 24-month- compared to 2- to 4-month-old male rats. These age-related effects on K+ stimulation were completely abolished with the addition of tetrodotoxin (1 microM) to the superfusion medium. Moreover, no difference in stimulated DA release was obtained between these two age groups following amphetamine stimulation (10 microM).
与2至4月龄的雄性大鼠相比，18至24月龄雄性大鼠的纹状体组织碎片在超灌注状态下对30 mM钾（K+）刺激释放内源性多巴胺（DA）的能力显著减弱。在超灌注培养基中添加河豚毒素（1 microM）后，这些与年龄相关的对K+刺激的影响完全消除。此外，在苯丙胺刺激（10 microM）后，这两个年龄组之间的刺激DA释放没有差异。
