Becker J B, Beer M E, Robinson T E
Brain Res. 1984 Oct 8;311(1):157-60. doi: 10.1016/0006-8993(84)91410-0.
The release of endogenous dopamine (DA) from rat striatal tissue was studied in an in vitro superfusion system following hormonal manipulations in vivo. Progesterone treatment in estrogen-primed ovariectomized female rats potentiated DA release stimulated either by amphetamine or potassium (K+). In addition, the amount of striatal DA released in response to K+-stimulation was influenced by the light-dark cycle. We conclude that striatal DA release is modulated by ovarian hormones, and suggest that ovarian hormone modulation of presynaptic striatal DA activity may contribute to well-known estrous cycle dependent variations in some non-reproductive behaviors.
在体内进行激素处理后，利用体外超灌流系统研究了大鼠纹状体组织中内源性多巴胺（DA）的释放。在雌激素预处理的去卵巢雌性大鼠中，孕酮处理增强了由苯丙胺或钾（K+）刺激引起的DA释放。此外，对K+刺激产生反应而释放的纹状体DA量受明暗周期影响。我们得出结论，纹状体DA释放受卵巢激素调节，并提出卵巢激素对突触前纹状体DA活性的调节可能导致一些非生殖行为中众所周知的发情周期依赖性变化。
