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小鼠味觉细胞中感受器电位的电压钳和电流钳记录。

Voltage- and current-clamp recordings of the receptor potential in mouse taste cell.

作者信息

Tonosaki K, Funakoshi M

机构信息

Department of Oral Physiology, School of Dentistry, Asahi University, Gifu, Japan.

出版信息

Brain Res. 1988 Apr 5;445(2):363-6. doi: 10.1016/0006-8993(88)91200-0.

DOI:10.1016/0006-8993(88)91200-0
PMID:3370469
Abstract

Intracellular recordings were obtained using the current-clamp and voltage-clamp techniques. When the taste cell membrane was voltage-clamped, the sucrose stimulus induced an inward current accompanied by a membrane resistance increase while the NaCl stimulus induced an inward current accompanied by a membrane resistance decrease. These phenomena indicated that sucrose and NaCl have quite a different generation mechanism of taste responses.

摘要

使用电流钳和电压钳技术进行细胞内记录。当味觉细胞膜被电压钳制时,蔗糖刺激诱导出内向电流,同时伴有膜电阻增加,而氯化钠刺激诱导出内向电流,同时伴有膜电阻降低。这些现象表明,蔗糖和氯化钠的味觉反应产生机制有很大不同。

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引用本文的文献

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The transduction channel TRPM5 is gated by intracellular calcium in taste cells.转导通道TRPM5由味觉细胞内的钙门控。
J Neurosci. 2007 May 23;27(21):5777-86. doi: 10.1523/JNEUROSCI.4973-06.2007.
2
Amiloride-blockable sodium currents in isolated taste receptor cells.
J Membr Biol. 1988 Nov;105(3):245-55. doi: 10.1007/BF01871001.
3
Perspectives of taste reception.味觉感受的观点。
J Membr Biol. 1989 Nov;112(1):1-8. doi: 10.1007/BF01871158.