Department of Acupuncture and Moxibustion, the Second Hospital of Jilin University, Changchun, China.
Department of Traditional Chinese Medicine, the Second Hospital of Jilin University, Changchun, China.
Brain Behav. 2021 May;11(5):e02100. doi: 10.1002/brb3.2100. Epub 2021 Mar 11.
Along with the aging of the world population, the incidence rate of Alzheimer's disease (AD) has been increasing. At present, AD has become one of the most serious problems faced by modern medicine. Studies have shown that estrogen has a positive effect on AD, but estrogen has the side effect of leading to tumors. Recent in vivo studies have shown that genistein, one of the selective estrogen receptor modulators (SERMs), can improve brain function through the blood-brain barrier (BBB), antagonize the toxicity of amyloid β-protein (Aβ), that is, to inhibit neurotoxicity due to aggregation of beta amyloid protein, and have neuroprotective effects. In addition, the use of Gen can avoid the risk of endometrial cancer and breast cancer caused by estrogen therapy while exerting an estrogen-like effect, which has some potential for the delay and treatment of AD.
随着世界人口老龄化，阿尔茨海默病（AD）的发病率一直在上升。目前，AD 已成为现代医学面临的最严重问题之一。研究表明，雌激素对 AD 有积极作用，但雌激素有导致肿瘤的副作用。最近的体内研究表明，染料木黄酮，一种选择性雌激素受体调节剂（SERMs），可以通过血脑屏障（BBB）改善大脑功能，拮抗淀粉样β-蛋白（Aβ）的毒性，即抑制由于β淀粉样蛋白聚集引起的神经毒性，并具有神经保护作用。此外，使用染料木黄酮可以避免雌激素治疗引起的子宫内膜癌和乳腺癌的风险，同时发挥类似雌激素的作用，这为 AD 的延迟和治疗提供了一些潜力。
