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基于网络药理学方法和分子对接分析探讨“肉苁蓉-远志”治疗阿尔茨海默病的作用机制

Mechanism of action of "cistanche deserticola-Polygala" in treating Alzheimer's disease based on network pharmacology methods and molecular docking analysis.

作者信息

Wang Shaoqiang, Wang Yifan

机构信息

School of Information and Control Engineering, Qingdao University of Technology, Qingdao, China.

The Seventh Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, China.

出版信息

IET Syst Biol. 2024 Dec;18(6):271-284. doi: 10.1049/syb2.12100. Epub 2024 Oct 11.

DOI:10.1049/syb2.12100
PMID:39393018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11665837/
Abstract

This article used network pharmacology, molecular docking, GEO analysis, and Gene Set Enrichment Analysis to obtain 38 main chemical components and 66 corresponding targets involved in Alzheimer's disease (AD) treatment in "Cistanche deserticola-Polygala". Through further Gene Ontology and Kyoto Encyclopaedia of Genes and Genomes enrichment analysis, we obtained AD signalling pathways, calcium signalling pathways, and other signalling pathways related to the treatment of AD with "Cistanche deserticola-Polygala". Molecular docking showed that most of the core chemical components had good binding ability with the core targets. This article aims to reveal the mechanism of "Cistanche deserticola-Polygala" in treating AD and provide a basis for the treatment of AD with "Cistanche deserticola-Polygala".

摘要

本文运用网络药理学、分子对接、基因表达综合数据库（GEO）分析以及基因集富集分析，从“肉苁蓉-远志”中获取了38种参与阿尔茨海默病（AD）治疗的主要化学成分及66个相应靶点。通过进一步的基因本体论（Gene Ontology）和京都基因与基因组百科全书（Kyoto Encyclopaedia of Genes and Genomes）富集分析，我们获得了与“肉苁蓉-远志”治疗AD相关的AD信号通路、钙信号通路等信号通路。分子对接表明，大多数核心化学成分与核心靶点具有良好的结合能力。本文旨在揭示“肉苁蓉-远志”治疗AD的作用机制，为其治疗AD提供依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a201/11665837/5e423dc6c056/SYB2-18-271-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a201/11665837/bcb1475d8ed2/SYB2-18-271-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a201/11665837/b361e0a9946c/SYB2-18-271-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a201/11665837/5095c0951a70/SYB2-18-271-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a201/11665837/47f93c779a58/SYB2-18-271-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a201/11665837/2d542fa3247e/SYB2-18-271-g010.jpg
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