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神经肽Y刺激大鼠脑微型切片中的肌醇磷脂水解。

Neuropeptide Y stimulates inositol phospholipid hydrolysis in rat brain miniprisms.

作者信息

Hinson J, Rauh C, Coupet J

机构信息

American Cyanamid Company, Medical Research Division, Lederle Laboratories, Pearl River, NY 10965.

出版信息

Brain Res. 1988 Apr 19;446(2):379-82. doi: 10.1016/0006-8993(88)90898-0.

Abstract

Neuropeptide Y (NPY) stimulates the hydrolysis of inositol phospholipid in rat brain miniprisms. The stimulation was two-fold in the frontal cortex and in the hippocampus, and 1.5-fold in the striatum. NPY produced no significant effects on basal inositol monophosphate levels in hypothalamic miniprisms. However, those basal levels were much higher than in the other brain regions.

摘要

神经肽Y(NPY)可刺激大鼠脑薄片中肌醇磷脂的水解。在额叶皮质和海马体中,这种刺激作用为两倍,在纹状体中为1.5倍。NPY对下丘脑薄片中的基础肌醇单磷酸水平没有显著影响。然而,这些基础水平远高于其他脑区。

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