Fowler C J, Magnusson O, Mohammed A K, Danysz W, Archer T
Eur J Pharmacol. 1986 Apr 29;123(3):401-7. doi: 10.1016/0014-2999(86)90715-6.
The breakdown of inositol phospholipid (PI) stimulated by hippocampal noradrenaline in rat miniprisms in vitro was used as an index of alpha 1-adrenoceptor function after selective noradrenergic denervation. Selective denervation was produced by microinjections of 6-hydroxydopamine (6-OHDA) into either the dorsal noradrenergic bundle (DNAB) or the locus coeruleus (LC), or by systemic treatment with the noradrenergic neurotoxin DSP4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine). Fourteen days after these treatments, there was a large depletion of cortical noradrenaline but no change in the stimulation of hippocampal PI breakdown by noradrenaline. It is concluded that selective noradrenergic denervation under the conditions used here does not lead to hippocampal alpha 1-adrenoceptor supersensitivity as assessed by noradrenaline-stimulated PI breakdown.
在体外大鼠微小脑片中，海马去甲肾上腺素刺激的肌醇磷脂（PI）分解被用作选择性去甲肾上腺素能神经支配后α1 -肾上腺素能受体功能的指标。通过将6 - 羟基多巴胺（6 - OHDA）微量注射到背侧去甲肾上腺素能束（DNAB）或蓝斑（LC）中，或通过用去甲肾上腺素能神经毒素DSP4（N -（2 - 氯乙基）- N - 乙基 - 2 - 溴苄胺）进行全身治疗来产生选择性神经支配。这些处理后14天，皮质去甲肾上腺素大量耗竭，但去甲肾上腺素对海马PI分解的刺激没有变化。由此得出结论，在此所用条件下的选择性去甲肾上腺素能神经支配不会导致如通过去甲肾上腺素刺激的PI分解所评估的海马α1 -肾上腺素能受体超敏反应。
