Pròspere Facial Institute, No. 300, Avenida Moema.
Department of Stomatology, School of Dentistry, University of São Paulo, No 2227, Avenida Professor Lineu Prestes, São Paulo, SP, Brazil.
J Craniofac Surg. 2021;32(2):e120-e122. doi: 10.1097/SCS.0000000000006847.
Nose augmentation with Hyaluronic acid (HA) fillers has been considered the preferred technique for minimally invasive cosmetic procedures. Despite severe complications related to HA injection are rare, none of the existing treatment protocols has been established as standard. The aim of this report is to present an alternative approach to treat nasal skin necrosis related to HA injection. A high dose of hyaluronidase - 6000 IU was applied in the nose, for the purpose of reversing a necrotic process. The present findings suggest that a high dose of hyaluronidase could be a promising approach to treat severe nasal skin necrosis caused by HA filler.
透明质酸（HA）填充剂进行鼻部整形已被认为是微创美容程序的首选技术。尽管与 HA 注射相关的严重并发症很少见，但尚未确立任何现有治疗方案作为标准。本报告的目的是提出一种治疗与 HA 注射相关的鼻皮肤坏死的替代方法。在鼻子中应用了高剂量的透明质酸酶-6000IU，以逆转坏死过程。目前的研究结果表明，高剂量透明质酸酶可能是治疗由 HA 填充剂引起的严重鼻皮肤坏死的一种有前途的方法。
