Germani Marcelo, Alegria Panmella, Giro Gabriela, Munoz-Lora Victor R M
Department of Periodontology and Implantology, University of Guarulhos, São Paulo, Brazil.
Private Office, São Paulo, Brazil.
J Oral Biol Craniofac Res. 2024 May-Jun;14(3):339-341. doi: 10.1016/j.jobcr.2024.04.006. Epub 2024 Apr 22.
The growing popularity of soft tissue filler injections has brought attention to the associated risks, particularly vascular complications, and their treatments. This case report focuses on a 34-year-old female who developed nasal skin necrosis following hyaluronic acid (HA) filler injection for nasolabial fold (NLF) enhancement. Despite the careful procedure, complications emerged rapidly, emphasizing the critical importance of prompt diagnosis and intervention. A total of 10,000 turbidity reducing units (TRU) of hyaluronidase (HSE) were administered in a high-dose pulsed manner, alongside hyperbaric oxygen therapy. The patient experienced a gradual but significant improvement over 60 days. This case underscores the need for constant vigilance in aesthetic medicine and the potential consequences of even minute HA amounts, exceeding zero, in causing severe vascular events.
软组织填充剂注射日益普及，这引发了人们对相关风险的关注，尤其是血管并发症及其治疗方法。本病例报告聚焦于一名34岁女性，她在接受透明质酸（HA）填充剂注射以改善鼻唇沟（NLF）后出现了鼻部皮肤坏死。尽管手术操作谨慎，但并发症迅速出现，凸显了及时诊断和干预的至关重要性。以高剂量脉冲方式注射了总共10,000个浊度降低单位（TRU）的透明质酸酶（HSE），同时进行了高压氧治疗。患者在60天内逐渐但显著地康复。该病例强调了在美容医学中持续保持警惕的必要性，以及即使极微量（超过零）的HA也可能导致严重血管事件的潜在后果。
