Myomodulation (MyoMo) using hyaluronic acid (HA) fillers can be considered as a novel aesthetic treatment for gummy smile (GS). However, literature is still lacking information about this procedure. For this reason, the aim of the present case report was to describe a technique for MyoMo with HA as an efficient alternative for the management of GS. A 36-year-old male patient attended to our clinic complaining about excessive gingival exposure when smiling. After a clinical and digital assessment, poor bone support was observed in the premaxilla area, resulting in an increasing contraction of the levator labii superioris alaeque nasi and levator anguli oris. A multilayer approach with HA filling was performed in order to impair muscle movement and limit excessive lip elevation. As a result, a reduction on the elevation of the upper lip while smiling was achieved, and an improvement on GS was achieved. Thus, it can be proposed that Myomo with HA acid may be an effective treatment for GS, with lasting and satisfactory results. However, high-quality studies are required in order to compare patient's satisfaction with this treatment and any other possible alternative.