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本文引用的文献

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Phase I Study of Elacestrant (RAD1901), a Novel Selective Estrogen Receptor Degrader, in ER-Positive, HER2-Negative Advanced Breast Cancer.Elacestrant（RAD1901），一种新型选择性雌激素受体降解剂，在 ER 阳性、HER2 阴性晚期乳腺癌中的 I 期研究。
J Clin Oncol. 2021 Apr 20;39(12):1360-1370. doi: 10.1200/JCO.20.02272. Epub 2021 Jan 29.
2
The Dysregulated Pharmacology of Clinically Relevant Mutants is Normalized by Ligand-activated WT Receptor.临床上相关突变体的药理学失调可通过配体激活的 WT 受体来正常化。
Mol Cancer Ther. 2020 Jul;19(7):1395-1405. doi: 10.1158/1535-7163.MCT-19-1148. Epub 2020 May 7.
3
Elacestrant (RAD1901) exhibits anti-tumor activity in multiple ER+ breast cancer models resistant to CDK4/6 inhibitors.Elacestrant（RAD1901）在多种对 CDK4/6 抑制剂耐药的 ER+ 乳腺癌模型中表现出抗肿瘤活性。
Breast Cancer Res. 2019 Dec 18;21(1):146. doi: 10.1186/s13058-019-1230-0.
4
Alpelisib for -Mutated, Hormone Receptor-Positive Advanced Breast Cancer.阿培利司治疗 - 突变型、激素受体阳性晚期乳腺癌。
N Engl J Med. 2019 May 16;380(20):1929-1940. doi: 10.1056/NEJMoa1813904.
5
Constitutively active ESR1 mutations in gynecologic malignancies and clinical response to estrogen-receptor directed therapies.妇科恶性肿瘤中组成性激活的 ESR1 突变与雌激素受体靶向治疗的临床反应。
Gynecol Oncol. 2019 Jul;154(1):199-206. doi: 10.1016/j.ygyno.2019.04.010. Epub 2019 Apr 13.
6
Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERα and ERα Breast Cancer.选择性雌激素受体共价拮抗剂的发现用于 ERα 和 ERα 乳腺癌的治疗。
Cancer Discov. 2018 Sep;8(9):1176-1193. doi: 10.1158/2159-8290.CD-17-1229. Epub 2018 Jul 10.
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On the Treatment of Inoperable Cases of Carcinoma of the Mamma: Suggestions for a New Method of Treatment, with Illustrative Cases.论乳癌不可手术病例的治疗：一种新治疗方法的建议及实例说明
Trans Med Chir Soc Edinb. 1896;15:153-179.
8
Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations.ESR1 激活突变的等位基因特异性染色质募集和治疗弱点。
Cancer Cell. 2018 Feb 12;33(2):173-186.e5. doi: 10.1016/j.ccell.2018.01.004.
9
Selective estrogen receptor modulators (SERMs) and selective estrogen receptor degraders (SERDs) in cancer treatment.选择性雌激素受体调节剂（SERMs）和选择性雌激素受体降解剂（SERDs）在癌症治疗中的应用。
Pharmacol Ther. 2018 Jun;186:1-24. doi: 10.1016/j.pharmthera.2017.12.012. Epub 2017 Dec 28.
10
Menopausal Hormone Therapy and Long-term All-Cause and Cause-Specific Mortality: The Women's Health Initiative Randomized Trials.绝经激素治疗与全因及特定病因长期死亡率：妇女健康倡议随机试验
JAMA. 2017 Sep 12;318(10):927-938. doi: 10.1001/jama.2017.11217.

Next-Generation Endocrine Therapies for Breast Cancer.

作者信息

McDonnell Donald P, Wardell Suzanne E, Chang Ching-Yi, Norris John D

机构信息

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC.

出版信息

J Clin Oncol. 2021 Apr 20;39(12):1383-1388. doi: 10.1200/JCO.20.03565. Epub 2021 Mar 11.

DOI:10.1200/JCO.20.03565
PMID:33705209
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8274744/
Abstract
摘要