Department of Pharmaceutics, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, China.
Department of Pharmaceutics, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, China.
Adv Drug Deliv Rev. 2021 May;172:80-103. doi: 10.1016/j.addr.2021.02.019. Epub 2021 Mar 9.
Remarkable advances in nano delivery systems have provided new hope for tumor prevention, diagnosis and treatment. However, only limited clinical therapeutic effects against solid tumors were achieved. One of the main reasons is the presence of abundant physiological and pathological barriers in vivo that impair tumoral penetration and distribution of the nanodrugs. These barriers are related to the components of tumor microenvironment (TME) including abnormal tumor vasculature, rich composition of the extracellular matrix (ECM), and abundant stroma cells. Herein, we review the advanced strategies of TME remodeling to overcome these biological obstacles against nanodrug delivery. This review aims to offer a perspective guideline for the implementation of promising approaches to facilitate intratumoral permeation of nanodrugs through alleviation of biological barriers. At the same time, we analyze the advantages and disadvantages of the corresponding methods and put forward possible directions for the future researches.
纳米递药系统的显著进展为肿瘤的预防、诊断和治疗提供了新的希望。然而，针对实体瘤的临床治疗效果有限。主要原因之一是体内丰富的生理和病理屏障阻碍了纳米药物的肿瘤穿透和分布。这些屏障与肿瘤微环境（TME）的组成部分有关，包括异常的肿瘤血管、丰富的细胞外基质（ECM）组成和丰富的基质细胞。本文综述了 TME 重塑的先进策略，以克服纳米药物传递中这些生物障碍。本综述旨在为实施有前途的方法提供一个视角指南，以通过缓解生物屏障来促进纳米药物在肿瘤内的渗透。同时，我们分析了相应方法的优缺点，并提出了未来研究的可能方向。
