臭氧油局部治疗重度骨关节炎的疗效：一项随机、三盲、安慰剂对照研究。
Effectiveness of topical ozonated oil in severe osteoarthritis: A randomised, triple-blinded, placebo-controlled study.
机构信息
Graduate Program in Human Aging, University of Passo Fundo, Passo Fundo, Rio Grande do Sul, Brazil.
Clinical Hospital of Passo Fundo, Passo Fundo, Rio Grande do Sul, Brazil.
出版信息
Complement Ther Clin Pract. 2021 May;43:101351. doi: 10.1016/j.ctcp.2021.101351. Epub 2021 Mar 5.
BACKGROUND
Osteoarthritis is highly prevalent and a common locomotory disorder in the elderly. The treatments aim improves the quality of life. We aimed to evaluate the effectiveness of topical ozonated oil in relieving pain in patients with osteoarthritis.
DESIGN
A placebo-controlled, triple-blind, randomised controlled trial including osteoarthritis patients older than 50 years.
INTERVENTIONS
Eighty patients were randomly divided into two groups: treatment (ozonated oil) and placebo (non-ozonated oil). The oils were used twice a day for 60 days. Evaluations were performed using WOMAC (Western Ontario and McMaster Universities) and VAS (visual analogue scale) and laboratory analysis.
RESULTS
Pain relief was observed in all groups except in the placebo group where patients are diagnosed with severe osteoarthritis (degree 4) (p-value treatment and placebo group: 0.021 and 0.345, respectively).
CONCLUSIONS
For the first time, the pain relief in patients with severe osteoarthritis was demonstrated by the use of topical ozonated oil.
背景
骨关节炎在老年人中普遍存在且是一种常见的运动障碍。治疗旨在改善生活质量。我们旨在评估局部臭氧油治疗骨关节炎患者疼痛的有效性。
设计
一项安慰剂对照、三盲、随机对照试验，纳入 50 岁以上的骨关节炎患者。
干预措施
80 名患者随机分为两组：治疗组（臭氧油）和安慰剂组（非臭氧油）。每天使用两次油，持续 60 天。使用 WOMAC（西安大略和麦克马斯特大学）和 VAS（视觉模拟量表）以及实验室分析进行评估。
结果
除了在诊断为严重骨关节炎（4 级）的安慰剂组患者中观察到疼痛缓解外，所有组均观察到疼痛缓解（p 值治疗组和安慰剂组分别为 0.021 和 0.345）。
结论
这是首次使用局部臭氧油治疗严重骨关节炎患者的疼痛缓解。
Zotero 插件