Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran; Orthopedic Department, Shiraz University of Medical Sciences, Shiraz, Iran.
Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran.
Complement Ther Med. 2019 Dec;47:102183. doi: 10.1016/j.ctim.2019.08.017. Epub 2019 Aug 22.
Sesame oil is an herbal product that has been used to treat the joints pain in several traditional medicines. In this study, we evaluated the efficacy of topical sesame oil versus diclofenac gel in patients with knee osteoarthritis (OA).
One hundred and four patients were randomly enrolled in two arms of the trial. Patients were treated by topical sesame oil or diclofenac (three times a day) for 4 weeks. Outcome measures were knee pain via visual analogue scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire, knee joint's flexion angle, 8-meter walk test and number of used analgesics. Patients were evaluated at baseline, 2 and then 4 weeks after the intervention.
At the follow-up visits, sesame oil was not inferior to diclofenac regarding scores of WOMAC pain, 8-meter walk test, and knee flexion angle. Although, its non-inferiority was not proved regarding scores of VAS, WOMAC stiffness, and WOMAC total at the 4 week. Moreover, sesame oil was not inferior to diclofenac regarding consumed analgesics.
It seems that the topical sesame oil was non-inferior to diclofenac gel on the reduction of the knee OA pain and improvement of some indicators of its function.
芝麻油是一种草药产品，在几种传统药物中被用于治疗关节疼痛。在这项研究中，我们评估了局部芝麻油与双氯芬酸钠凝胶治疗膝骨关节炎（OA）患者的疗效。
104 名患者被随机分为两组进行试验。患者接受局部芝麻油或双氯芬酸钠（每天三次）治疗 4 周。通过视觉模拟评分（VAS）、西安大略和麦克马斯特大学骨关节炎指数（WOMAC）问卷、膝关节屈曲角度、8 米步行试验和使用的镇痛药数量来评估疗效。患者在基线、2 周和干预后 4 周进行评估。
随访时，芝麻油在 WOMAC 疼痛评分、8 米步行试验和膝关节屈曲角度方面与双氯芬酸钠无差异。然而，在第 4 周时，VAS、WOMAC 僵硬和 WOMAC 总分方面，其非劣效性并未得到证实。此外，芝麻油在消耗的镇痛药方面与双氯芬酸钠无差异。
局部芝麻油在减轻膝骨关节炎疼痛和改善其功能的一些指标方面与双氯芬酸钠凝胶相当。
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