Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, PR China.
Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, PR China; Key Laboratory of Health Bioinformatics, Chinese Academy of Sciences, Shenzhen, 518055, PR China.
Colloids Surf B Biointerfaces. 2021 Jun;202:111667. doi: 10.1016/j.colsurfb.2021.111667. Epub 2021 Mar 1.
In the development of biocompatible materials for biomedical applications, infections and their resulting inflammation responses are important issues caused typically by the adhesion of micro-organisms on medical devices. Recently slippery liquid-infused porous surfaces (SLIPS) has provided a new strategy for anti-biofouling and low-adhesion surfaces, however, there are still some bottlenecks in practical uses, particularly the loss of lubricant significantly restricts the durability and stability of SLIPS. In this paper, we micro-fabricated well-controlled micro-cavities with different profiles (vertical or inclined walls) to investigate the long-term anti-biofouling effect of SLIPS. We explored microstructure geometries in two aspects: the aspect ratio and the slope angle relevant with the Laplace pressure and the oil contact area which lead to different oil-locking abilities. High aspect ratio and inclined slope were demonstrated with better oil-locking ability as well as significantly increased anti-fouling performances. Under the same experimental setup, the Escherichia coli and Staphylococcus aureus bacteria coverage on SLIPS with 80 μm-depth 20° inclined micro-cavities was only ∼30 % of that with vertical micro-cavities, while increasing aspect ratio by 4 times induced ∼3 times enhanced anti-fouling effect. On basis of these findings, we propose the enhanced SLIPS with inclined microstructures to achieve better oil-locking ability and long-term anti-biofouling performance, which may broaden many practical applications of SLIPS.
在生物医学应用中开发生物相容性材料时，感染及其引发的炎症反应是一个重要问题，通常是由微生物在医疗设备上的黏附引起的。最近，滑液浸润多孔表面（SLIPS）为抗生物污染和低黏附表面提供了一种新策略，然而，在实际应用中仍然存在一些瓶颈，特别是润滑剂的损失极大地限制了 SLIPS 的耐用性和稳定性。在本文中，我们通过微制造具有不同轮廓（垂直或倾斜壁）的可控微腔来研究 SLIPS 的长期抗生物污染效果。我们从两个方面探索了微结构几何形状：与 Laplace 压力和油接触面积相关的纵横比和斜率角度，这导致了不同的油锁定能力。高纵横比和倾斜斜率表现出更好的油锁定能力以及显著提高的抗污染性能。在相同的实验设置下，大肠杆菌和金黄色葡萄球菌在具有 80μm 深 20°倾斜微腔的 SLIPS 上的覆盖度仅约为具有垂直微腔的覆盖度的 30%，而纵横比增加 4 倍则导致抗污染效果增强约 3 倍。基于这些发现，我们提出了具有倾斜微结构的增强型 SLIPS，以实现更好的油锁定能力和长期抗生物污染性能，这可能会拓宽 SLIPS 的许多实际应用。
