Fiel R J, Musser D A, Mark E H, Mazurchuk R, Alletto J J
Department of Biophysics, Roswell Park Memorial Institute, Buffalo, New York 14263.
Magn Reson Imaging. 1990;8(3):255-9. doi: 10.1016/0730-725x(90)90097-l.
Four manganese meso-sulfonatophenyl porphyrins were prepared, characterized and investigated for their potential as tumor-specific MRI contrast-enhancing agents in mice bearing subcutaneous implants of a mammary carcinoma (SMT-F). The trisulfonated tetraphenyl porphyrin, MnTPPS3 presented the most favorable profile: bio-distribution, tumor concentration and tumor relaxivity, when compared at 24 hr postinjection. Imaging experiments revealed that a time-dependent delineation of tumor morphology occurs in response to MnTPPS3 that appears to correlate with necrotic regions of the tumor.
