Schackert G, Fidler I J
Department of Cell Biology, University of Texas, M. D. Anderson Hospital and Tumor Institute, Houston 77030.
Cancer Res. 1988 Jun 15;48(12):3478-84.
Different subpopulations of cells from two different murine melanomas (K-1735 and B16) and a fibrosarcoma (UV-2237) were injected into the internal carotid artery of anesthetized syngeneic mice. Despite the common route of tumor cell injection, tumor lesions in the brain were unique to each tumor type and developed at different sites in the brain. Gross and histological examinations revealed that different subpopulations of cells derived from the K-1735 melanoma produced only parenchymal lesions, cells of the B16 melanoma produced lesions in the meninges and ventricles, and cells of the UV-2237 fibrosarcoma produced lesions throughout the brain. This site specificity for tumor growth was not due to the initial tumor cell arrest in the microvasculature of different regions-areas in the brain as evidenced by detailed studies with radiolabeled cells. The site specificity of this experimental brain metastasis was not random and correlated well with the clinical situation. The exact interactions of tumor cells with different microenvironments in the brain need further elucidation.
将来自两种不同小鼠黑色素瘤（K - 1735和B16）以及一种纤维肉瘤（UV - 2237）的不同细胞亚群注入麻醉的同基因小鼠的颈内动脉。尽管肿瘤细胞注射途径相同，但脑内的肿瘤病变因肿瘤类型而异，且在脑内不同部位形成。大体和组织学检查显示，源自K - 1735黑色素瘤的不同细胞亚群仅产生实质病变，B16黑色素瘤的细胞在脑膜和脑室产生病变，而UV - 2237纤维肉瘤的细胞在全脑产生病变。这种肿瘤生长的部位特异性并非由于最初肿瘤细胞在脑内不同区域的微血管中停滞，放射性标记细胞的详细研究证明了这一点。这种实验性脑转移的部位特异性并非随机，且与临床情况密切相关。肿瘤细胞与脑内不同微环境的确切相互作用需要进一步阐明。
