黄芪甲苷治疗可降低糖尿病大鼠血糖、调节血脂、保护肝功能。

OBJECTIVES

To investigate the effects of astragaloside IV on blood glucose, blood lipids, and liver function in diabetic rats.

METHODS

Fifty diabetic rats were randomly placed into five groups (n = 10 each): the diabetes mellitus (DM) group received intragastric saline, the metformin hydrochloride group received intragastric metformin hydrochloride, and the astragaloside-30, -60, and -120 groups received intragastric astragaloside 30 mg/kg, 60 mg/kg, and 120 mg/kg for 28 days, respectively. Ten non-diabetic rats received intragastric saline as controls.

RESULTS

Relative to the DM group, fasting blood glucose, triglyceride, total cholesterol, serum alanine transaminase, and serum aspartate aminotransferase levels decreased in the astragaloside-60 and astragaloside-120 groups; serum alkaline phosphatase decreased solely in the astragaloside-120 group. Serum superoxide dismutase (SOD), glutathione (GSH-Px), and catalase (CAT) levels were elevated, while maleic dialdehyde (MDA) decreased in the astragaloside-120 group, relative to the DM group. Relative to the DM group, the liver index and liver cell apoptosis rate were reduced, while histopathological changes in liver tissue were ameliorated in the astragaloside groups; moreover, liver tissue SOD, GSH-Px, and CAT levels were increased, while liver tissue MDA was reduced.

CONCLUSIONS

Astragaloside IV can lower blood glucose, regulate blood lipids, and protect liver function in diabetic rats.

目的

观察黄芪甲苷对糖尿病大鼠血糖、血脂及肝功能的影响。

方法

50 只糖尿病大鼠随机分为 5 组（每组 10 只）：糖尿病组给予生理盐水灌胃，盐酸二甲双胍组给予盐酸二甲双胍灌胃，黄芪甲苷 30、60、120 mg/kg 组分别给予相应剂量的黄芪甲苷灌胃，连续 28 天。10 只正常大鼠给予生理盐水灌胃作为正常对照组。

结果

与糖尿病组比较，黄芪甲苷 60、120 mg/kg 组大鼠空腹血糖、三酰甘油、总胆固醇、血清丙氨酸氨基转移酶、天门冬氨酸氨基转移酶水平降低，黄芪甲苷 120 mg/kg 组大鼠血清碱性磷酸酶降低；黄芪甲苷 120 mg/kg 组大鼠血清超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）、过氧化氢酶（CAT）水平升高，丙二醛（MDA）水平降低。与糖尿病组比较，黄芪甲苷各剂量组大鼠肝指数和肝细胞凋亡率降低，肝组织病理损伤减轻；黄芪甲苷各剂量组大鼠肝组织 SOD、GSH-Px、CAT 水平升高，MDA 水平降低。