Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, People's Republic of China.
Sino-Danish College of University of Chinese Academy of Sciences, Beijing, People's Republic of China.
Cogn Neuropsychiatry. 2021 May;26(3):166-182. doi: 10.1080/13546805.2021.1899906. Epub 2021 Mar 11.
Effort-reward imbalance (ERI) is a typical psychosocial stress. Schizotypal traits are attenuated features of schizophrenia in the general population. According to the diathesis-stress model, schizotypal traits and psychosocial stress contribute to the onset of schizophrenia. However, few studies examined the effects of these factors on brain alterations. This study aimed to examine relationships between ERI, schizotypal traits and brain structures and functions.
We recruited 37 (13 male, 24 female) participants with high levels of schizotypal traits and 36 (12 male, 24 female) participants with low levels of schizotypal traits by the Schizotypal Personality Questionnaire (SPQ). The Chinese school version of the effort-reward imbalance questionnaire (C-ERI-S) was used to measure ERI. We conducted the voxel-based morphometry (VBM) and whole brain resting-state functional connectivity (rsFC) analysis using reward or stress-related regions as seeds.
Participants with high levels of schizotypal traits were more likely to perceive ERI. The severity of ERI was correlated with grey matter volume (GMV) reduction of the left pallidum and altered rsFC among the prefrontal, striatum and cerebellum in participants with high levels of schizotypal traits.
ERI is associated with GMV reduction and altered rsFC in individuals with high levels of schizotypal traits.
努力-回报失衡（ERI）是一种典型的心理社会应激。精神分裂症特质是一般人群中精神分裂症的减弱特征。根据素质-应激模型，精神分裂症特质和心理社会应激会导致精神分裂症的发生。然而，很少有研究探讨这些因素对大脑变化的影响。本研究旨在探讨 ERI、精神分裂症特质与大脑结构和功能之间的关系。
我们通过精神分裂症特质问卷（SPQ）招募了 37 名（男性 13 名，女性 24 名）高精神分裂症特质和 36 名（男性 12 名，女性 24 名）低精神分裂症特质的参与者。使用中文版努力-回报失衡问卷（C-ERI-S）来衡量 ERI。我们使用奖励或应激相关区域作为种子进行基于体素的形态测量学（VBM）和全脑静息状态功能连接（rsFC）分析。
高精神分裂症特质的参与者更容易感知 ERI。ERI 的严重程度与高精神分裂症特质参与者的左侧苍白球灰质体积（GMV）减少以及前额叶、纹状体和小脑之间的 rsFC 改变相关。
ERI 与高精神分裂症特质个体的 GMV 减少和 rsFC 改变有关。
