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腹腔镜袖状胃切除术 12 个月后阻塞性睡眠呼吸暂停综合征对人体测量参数的影响。

The influence of obstructive sleep apnea syndrome on anthropometric parameters at 12 months after laparoscopic sleeve gastrectomy.

机构信息

Diabetes, Nutrition and Metabolic Diseases Department, "Grigore T. Popa" University of Medicine and Pharmacy, Str. Universității 16, 700115, Iași, Romania.

"Sf. Spiridon" Clinical Emergency Hospital, Iași, Romania.

出版信息

Sci Rep. 2021 Mar 11;11(1):5781. doi: 10.1038/s41598-021-85192-8.

Abstract

The aim of this study was to assess the influence of obstructive sleep apnea syndrome (OSAS) on the change in anthropometric parameters and body composition, in patients undergoing laparoscopic sleeve gastrectomy (LSG). This prospective study included patients undergoing LSG who had pre-operative polysomnography data and were also evaluated at six and 12 months after surgery. All patients included also had whole body composition analysis data before surgery and at six and 12 months after surgery. The results are presented in comparison between patients with and without OSAS. We included 73 patients in the analysis with a mean ± SD age and body mass index (BMI) of 40.3 ± 10.9 years and 45.4 ± 6.3 kg/m, respectively. As compared to the baseline levels, at 6 months there was a significant decrease in BMI, weight, waist circumference, serum glucose and HbA1c. At 12 months there was no further decrease as compared to the 6 months levels, irrespective of OSAS status. We observed a significant decrease at 6 months in percentage of fat, in both types of patients. However, as compared to the 6 months levels, at 12 months the percent fat had a significant decrease only in patients without OSAS (- 4.6%, 95% CI - 7.6 to - 1.7%) and not in those with OSAS (- 2.2%, 95% CI - 4.5 to 0.2%). In our study, patients with OSAS showed a similar decrease in different anthropometric parameters as those without OSAS after LSG. However, at 12 months of follow-up there was a significant decrease in the percent fat only in patients without OSAS.

摘要

本研究旨在评估阻塞性睡眠呼吸暂停综合征(OSAS)对腹腔镜袖状胃切除术(LSG)患者的人体测量参数和身体成分变化的影响。这项前瞻性研究纳入了术前多导睡眠图数据,并在术后 6 个月和 12 个月进行评估的接受 LSG 的患者。所有纳入的患者还在术前和术后 6 个月和 12 个月进行了全身成分分析。结果以有和无 OSAS 的患者进行比较。我们分析了 73 例患者,平均年龄和体重指数(BMI)分别为 40.3 ± 10.9 岁和 45.4 ± 6.3 kg/m。与基线水平相比,6 个月时 BMI、体重、腰围、血清葡萄糖和 HbA1c 显著下降。与 6 个月时的水平相比,12 个月时无进一步下降,与 OSAS 状态无关。我们观察到两组患者在 6 个月时脂肪百分比均显著下降。然而,与 6 个月时的水平相比,在 12 个月时,无 OSAS 的患者脂肪百分比显著下降(-4.6%,95%CI -7.6 至-1.7%),而 OSAS 患者则没有(-2.2%,95%CI -4.5 至 0.2%)。在我们的研究中,与无 OSAS 的患者相比,OSAS 患者在 LSG 后不同的人体测量参数也有类似的下降。然而,在 12 个月的随访中,只有无 OSAS 的患者脂肪百分比显著下降。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46c2/7952692/f331eb145016/41598_2021_85192_Fig1_HTML.jpg

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