Frigui S, Messadi A A, Thabet L
Laboratoire de Biologie Médicale et Banque du Sang, Centre de Traumatologie et des Grands Brûlés de Ben Arous, Tunisie.
Service de Réanimation des Brûlés, Centre de Traumatologie et des Grands Brûlés de Ben Arous, Tunisie.
Ann Burns Fire Disasters. 2020 Dec 31;33(4):304-311.
Pseudomonas æruginosa (PA) is among the major agents of infection in burns. Multidrug-resistant strains are commonly isolated, which hampers the management of these patients. Our purpose was to study the incidence density of PA colonization and PA infection and to investigate the antibiotic susceptibility of strains isolated in patients hospitalized in the Trauma and Burn Center's Burn Unit (TBC-BU) in Tunisia. It is a retrospective study including 1649 non-repetitive strains of PA during an 8-year period (2012- 2019). PA was the most common organism in TBC-BU bacterial ecology (15%). The incidence density of PA colonization and PA infection was 16.1‰ days of in-patient stay (DH) and 16.5‰ DH, respectively. A positive and statistically significant correlation was found between PA colonization and PA infection (rs=1; p=0,004). The colonization strains were mainly isolated from skin (25.1%) and central catheters (22.3%). Bacteremia was the most common infection (19.5%). The skin was the most common source of bacteremia (22.1%) followed by central catheters (18.3%). The highest rates of antibiotic resistance were found with piperacillin-tazobactam (72.4%), ceftazidime (49.4%), meropenem (74%), imipenem (70.5%), amikacin (74.6%), ciprofloxacin (56.5%) and fosfomycin (35.3%). We did not identify any colistin-resistant strain. The multidrug resistance rate was 78%. The metallo-carbapenemase-producing strains rate was 14.4%.
铜绿假单胞菌（PA）是烧伤感染的主要病原体之一。多药耐药菌株普遍存在，这给这些患者的治疗带来了困难。我们的目的是研究PA定植和PA感染的发病密度，并调查在突尼斯创伤与烧伤中心烧伤科（TBC - BU）住院患者中分离出的菌株的抗生素敏感性。这是一项回顾性研究，在8年期间（2012 - 2019年）纳入了1649株非重复的PA菌株。PA是TBC - BU细菌生态中最常见的微生物（15%）。PA定植和PA感染的发病密度分别为每住院日（DH）16.1‰和16.5‰。PA定植与PA感染之间存在正相关且具有统计学意义（rs = 1；p = 0.004）。定植菌株主要从皮肤（25.1%）和中心静脉导管（22.3%）中分离出来。菌血症是最常见的感染类型（19.5%）。皮肤是菌血症最常见的来源（22.1%），其次是中心静脉导管（18.3%）。哌拉西林 - 他唑巴坦（72.4%）、头孢他啶（49.4%）、美罗培南（74%）、亚胺培南（70.5%）、阿米卡星（74.6%）、环丙沙星（56.5%）和磷霉素（35.3%）的耐药率最高。我们未发现任何对黏菌素耐药的菌株。多药耐药率为78%。产金属碳青霉烯酶菌株的比例为14.4%。
