Thabet L, Frigui S, Mellouli A, Gargouri M, Maamar B, Harzallal I, Boukadida J, Messadi A A
Laboratoire de Biologie Médicale et Banque du Sang, Centre de Traumatologie et des Grands Brûlés de Ben Arous, Tunisie.
Service de Pharmacie, Centre de Traumatologie et des Grands Brûlés de Ben Arous, Tunisie.
Ann Burns Fire Disasters. 2021 Sep 30;34(3):245-251.
Antibiotics are one of the greatest advances in modern medicine. Antibiotic resistance is one of the most serious threats to global health, aggravating the prognosis of immunocompromised patients, especially burn patients. Our objective was to study the consumption of antibiotics of critical importance according to the WHO and the correlation between antibiotic resistance in Pseudomonas æruginosa and the consumption of these antibiotics. Our study took place in the Medical Laboratory in collaboration with the Trauma and Burn Center's Burn Unit in Tunisia. In our retrospective study, 1384 non-repetitive strains of Pseudomonas æruginosa responsible for colonization or infection were included, between January 2012 and December 2019. Pseudomonas æruginosa was the most isolated bacterial strain in the service, with an average rate of 15.9% of the service's bacterial ecology. The antibiotic resistance rates tested were high: 77.1% to piperacillin-tazobactam, 56% to ceftazidime, 74.9% to imipenem, 78.8% to amikacin, 54.7% to ciprofloxacin and 32.8% to fosfomycin. Among our strains, 81.8% were multi drug-resistant strains. The analysis of the correlation between the level of consumption of antibiotics and the antibiotic resistance levels in Pseudomonas æruginosa showed that the increased consumption of piperacillin-tazobactam increased resistance not only to piperacillin-tazobactam but also to imipenem and amikacin as well as multi drug resistance. Similarly, the increase in the consumption of fosfomycin correlates with resistance to piperacillin-tazobactam and imipenem.
抗生素是现代医学最伟大的进步之一。抗生素耐药性是对全球健康最严重的威胁之一，会加重免疫功能低下患者的预后，尤其是烧伤患者。我们的目标是研究世界卫生组织认定的至关重要的抗生素的使用情况，以及铜绿假单胞菌的抗生素耐药性与这些抗生素使用之间的相关性。我们的研究是在突尼斯的医学实验室与创伤和烧伤中心的烧伤科合作进行的。在我们的回顾性研究中，纳入了2012年1月至2019年12月期间导致定植或感染的1384株非重复铜绿假单胞菌菌株。铜绿假单胞菌是该科室分离出最多的菌株，平均占该科室细菌生态的15.9%。检测的抗生素耐药率很高：哌拉西林-他唑巴坦为77.1%，头孢他啶为56%，亚胺培南为74.9%，阿米卡星为78.8%，环丙沙星为54.7%，磷霉素为32.8%。在我们的菌株中，81.8%是多重耐药菌株。抗生素使用水平与铜绿假单胞菌抗生素耐药水平之间的相关性分析表明，哌拉西林-他唑巴坦使用量的增加不仅会增加对哌拉西林-他唑巴坦的耐药性，还会增加对亚胺培南和阿米卡星的耐药性以及多重耐药性。同样，磷霉素使用量的增加与对哌拉西林-他唑巴坦和亚胺培南的耐药性相关。
