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丘疹脓疱型及眼部酒渣鼻伴疑似皮肤红斑狼疮巧合:一例报告

Papulopustular and Ocular Rosacea with an Alleged Coincidence of Cutaneous Lupus Erythematosus: A Case Report.

作者信息

Sitohang Irma Bernadette S, Parrol Firman, Fitri Eyleny Meisyah, Nora Rina La Distia

机构信息

Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

出版信息

Case Rep Dermatol. 2021 Feb 1;13(1):62-68. doi: 10.1159/000511495. eCollection 2021 Jan-Apr.

Abstract

Rosacea is a chronic inflammatory skin disease characterized by central facial erythema with or without ocular involvement. It is often difficult to distinguish rosacea from other malar rashes, one of which is acute cutaneous lupus erythematosus (CLE), particularly when there is an increase in antinuclear antibody (ANA) level. We report the case of a 16-year old woman with facial erythematous plaque accompanied by papules and pustules, reddened eyes, and swollen eyelids since the last one year. Dermoscopic examination revealed telangiectasia, and skin scraping examination with 20% potassium hydroxide identified the presence of . Further ocular examination also revealed blepharitis, dysfunction of Meibomian gland, cicatrix, and corneal neovascularization. The ANA titer was positive (1:320), while the anti-dsDNA was negative. The patient was treated according to standard treatment for rosacea. The patient showed a satisfactory response following 2 weeks of therapy. Signs of recurring red patches with papules, pustules, telangiectasia, and identification of on skin scraping examination led to the diagnosis of papulopustular rosacea. A positive ANA test may also be present in other diseases, e.g. acute CLE. Therefore, the diagnosis of rosacea remains a challenge. Thorough observation and examination must be done in order to yield an accurate diagnosis of rosacea.

摘要

酒渣鼻是一种慢性炎症性皮肤病,其特征为面部中央红斑,可伴有或不伴有眼部受累。酒渣鼻常难以与其他颧部皮疹区分开来,其中之一是急性皮肤型红斑狼疮(CLE),尤其是当抗核抗体(ANA)水平升高时。我们报告一例16岁女性病例,该患者自去年以来面部出现伴有丘疹和脓疱的红斑性斑块、眼睛发红及眼睑肿胀。皮肤镜检查发现有毛细血管扩张,用20%氢氧化钾进行皮肤刮屑检查发现存在……。进一步的眼部检查还发现睑缘炎、睑板腺功能障碍、瘢痕形成及角膜新生血管。ANA滴度呈阳性(1:320),而抗双链DNA为阴性。该患者接受了酒渣鼻的标准治疗。治疗2周后患者显示出满意的反应。反复出现的带有丘疹、脓疱、毛细血管扩张的红色斑块迹象以及皮肤刮屑检查发现……导致丘疹脓疱型酒渣鼻的诊断。ANA检测呈阳性在其他疾病如急性CLE中也可能出现。因此,酒渣鼻的诊断仍然是一项挑战。必须进行全面的观察和检查以便准确诊断酒渣鼻。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/588f/7923712/6f1ab472c223/cde-0013-0062-g01.jpg

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