Prakoeswa Flora Ramona Sigit, Maharani Faradiba, Fitriah Munawaroh, Nugraha Jusak, Soebono Hardyanto, Prasetyo Budi, Martini Santi, Husada Dominicus, Notobroto Hari Basuki, Listiawan Muhammad Yulianto, Endaryanto Anang, Prakoeswa Cita Rosita Sigit
Doctoral Program, Faculty of Medicine, Airlangga University, Surabaya, Indonesia.
Dermatology and Venereology Department, Faculty of Medicine, Universitas Muhammadiyah Surakarta, Surakarta, Indonesia.
Interdiscip Perspect Infect Dis. 2021 Feb 24;2021:8879809. doi: 10.1155/2021/8879809. eCollection 2021.
Leprosy, a chronic infection caused by , has a complex transmission problem that makes eradication programs difficult. New cases and ongoing transmission of leprosy in endemic areas make individuals living in endemic environments vulnerable to leprosy. This can be caused by the dysregulation of immune system in individuals living in leprosy-endemic areas. Although the number of male leprosy patients is higher, female leprosy patients have more impact on the family health status due to close contact with family members, roles in the household, and parenting. This could cause the increased number of children leprosy patients. We investigated the dysregulation of immune system by comparing IL-17 and FOXP3+ levels occurring in maternal and child leprosy patients in endemic and nonendemic areas. The results of the study found a statistically significant difference in IL-17 levels between the MB leprosy patient group and the control group (=0.048), where higher levels of IL-17 are observed in the control group. A significant difference also was found in FOXP3+ levels between the group of healthy children living in endemic and those living in nonendemic areas (=0.047), where higher FOXP3+ is observed in the healthy children living in endemic areas group.
麻风病是一种由……引起的慢性感染性疾病，其传播问题复杂，这使得根除计划难以实施。流行地区新出现的麻风病病例以及持续传播的情况，使得生活在流行环境中的个体易患麻风病。这可能是由于生活在麻风病流行地区的个体免疫系统失调所致。尽管男性麻风病患者数量较多，但女性麻风病患者由于与家庭成员密切接触、在家庭中的角色以及育儿等因素，对家庭健康状况的影响更大。这可能导致儿童麻风病患者数量增加。我们通过比较流行地区和非流行地区母婴麻风病患者中白细胞介素-17（IL-17）和叉头框蛋白3阳性（FOXP3+）水平，来研究免疫系统的失调情况。研究结果发现，多菌型麻风病患者组与对照组之间的IL-17水平存在统计学显著差异（P=0.048），对照组中IL-17水平更高。在生活在流行地区的健康儿童组和生活在非流行地区的健康儿童组之间，FOXP3+水平也存在显著差异（P=0.047），生活在流行地区的健康儿童组中FOXP3+水平更高。
