Prakoeswa Flora Ramona Sigit, Maharani Faradiba, Hidayat Saiful, Sari Winda Atika, Oktavriana Triasari, Prakoeswa Cita Rosita Sigit, Umborowati Menul Ayu, Pramuningtyas Ratih, Bestari Rochmadina Suci, Aisyah Riandini, Risanti Erika Diana, Dewi Listiana Masyita, Anam Ilham Hafizha Maulana
Department of Dermatology Venerology and Aesthetic, Faculty of Medicine, Universitas Muhammadiyah Surakarta, Surakarta, Central Java, Indonesia.
PKU Muhammadiyah Hospital, Surakarta, Indonesia.
Int J Inflam. 2025 Jun 20;2025:5855171. doi: 10.1155/ijin/5855171. eCollection 2025.
Psoriasis is a chronic inflammatory skin disease that exhibits a strong association with metabolic syndrome (MetS). The involvement of various proinflammatory cytokines in MetS is thought to play a critical role in the pathogenesis of psoriasis. This study aims to evaluate the impact of MetS on immunological markers (IL-17, IL-23, and FOXP3+ regulatory T cells), disease severity, and quality of life (QoL) among patients with psoriasis. This cross-sectional study involved 42 psoriasis patients, divided into two groups: 29 without MetS (Pso) and 13 with MetS (Pso-MetS). Clinical parameters such as blood pressure, fasting blood glucose, and triglyceride levels were measured. Immunological markers (IL-17, IL-23, and FOXP3+) were analyzed using ELISA. Psoriasis severity was assessed using the Psoriasis Area and Severity Index (PASI), and QoL was evaluated with the Dermatology Life Quality Index (DLQI). The Pso-MetS group was significantly older than the Pso group ( value = 0.003). Higher systolic ( value < 0.001), fasting glucose ( value = 0.002), and triglycerides ( value < 0.001) were observed in the Pso-MetS group. Lower HDL observed in the Pso-MetS group ( value = 0.004). FOXP3+ expression was significantly lower in the Pso-MetS group (=0.02), while waist circumference, diastolic blood pressure, IL-17, IL-23, PASI, and DLQI scores levels showed no significant differences. MetS is associated with immune dysregulation, evidenced by reduced FOXP3+ expression in psoriasis patients. Further studies are needed to explore the immunological link between psoriasis and MetS.
银屑病是一种慢性炎症性皮肤病，与代谢综合征（MetS）密切相关。各种促炎细胞因子参与MetS被认为在银屑病的发病机制中起关键作用。本研究旨在评估MetS对银屑病患者免疫标志物（IL-17、IL-23和FOXP3 +调节性T细胞）、疾病严重程度和生活质量（QoL）的影响。这项横断面研究纳入了42例银屑病患者，分为两组：29例无MetS（Pso）和13例有MetS（Pso-MetS）。测量了血压、空腹血糖和甘油三酯水平等临床参数。使用酶联免疫吸附测定法（ELISA）分析免疫标志物（IL-17、IL-23和FOXP3 +）。使用银屑病面积和严重程度指数（PASI）评估银屑病严重程度，并用皮肤病生活质量指数（DLQI）评估生活质量。Pso-MetS组明显比Pso组年龄大（值 = 0.003）。在Pso-MetS组中观察到更高的收缩压（值 < 0.001）、空腹血糖（值 = 0.002）和甘油三酯（值 < 0.001）。在Pso-MetS组中观察到更低的高密度脂蛋白（HDL）（值 = 0.004）。Pso-MetS组中FOXP3 +表达明显更低（=0.02），而腰围、舒张压、IL-17、IL-23、PASI和DLQI评分水平无显著差异。MetS与免疫失调有关，银屑病患者中FOXP +表达降低证明了这一点。需要进一步研究来探索银屑病与MetS之间的免疫联系。
