David Ruban Sabina, Christina Hilt Claudia, Petersen Thor
Department of Neurology, Aalborg University Hospital, Aalborg, Denmark.
Faculty of Health, Aarhus University, Aarhus, Denmark.
Mult Scler J Exp Transl Clin. 2021 Feb 24;7(1):2055217321996040. doi: 10.1177/2055217321996040. eCollection 2021 Jan-Mar.
Multiple sclerosis is a chronic disease leading to reduced quality of life.
To investigate whether motor and cognitive fatigue impact differently on aspects of quality of life among patients with multiple sclerosis, independently from bodily disability.
79 patients with multiple sclerosis from Aalborg University Hospital, Denmark were included in an observational, cross-sectional study. Each subject completed two separate questionnaires regarding fatigue (Fatigue Scale for Motor and Cognitive Functions and Modified Fatigue Impact Scale) and one regarding quality of life (Short Form 36). Disability was measured with the Expanded Disability Status Scale (EDSS)-scores obtained from patient records.
All fatigue scores were significantly correlated to all areas of quality of life (p < 0,05). This remained significant after adjustment for age, disease duration and EDSS-score. When looking at each type of fatigue separately, cognitive fatigue correlated mainly with mental health aspects of quality of life and motor fatigue with physical health areas of quality of life.
Increased motor and cognitive fatigue lead to a differential reduction in physical and mental quality of life, independently of bodily disability. This underlines the importance of proper assessment and treatment of fatigue among patients with multiple sclerosis.
多发性硬化症是一种导致生活质量下降的慢性疾病。
研究运动性疲劳和认知性疲劳对多发性硬化症患者生活质量各方面的影响是否不同，且独立于身体残疾因素。
丹麦奥尔堡大学医院的79名多发性硬化症患者纳入一项观察性横断面研究。每位受试者完成两份关于疲劳的独立问卷（运动和认知功能疲劳量表以及改良疲劳影响量表）和一份关于生活质量的问卷（简短健康调查问卷36项）。通过从患者记录中获取的扩展残疾状态量表（EDSS）评分来衡量残疾程度。
所有疲劳评分均与生活质量的所有领域显著相关（p < 0.05）。在对年龄、病程和EDSS评分进行调整后，这种相关性仍然显著。当分别观察每种类型的疲劳时，认知性疲劳主要与生活质量的心理健康方面相关，而运动性疲劳与生活质量的身体健康领域相关。
运动性疲劳和认知性疲劳的增加会导致身体和心理生活质量的差异性下降，且独立于身体残疾。这突出了对多发性硬化症患者疲劳进行适当评估和治疗的重要性。
