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男性患者出现伴有可触及淋巴结的瘙痒性乳腺肿块:一例病例报告。

Pruritic breast mass with palpable lymph nodes in a male patient: a case report.

作者信息

Long Quanyi, Fan Yuan, Zhang Jia, Li Hongjiang, Lv Qing

机构信息

Department of Breast Surgery, West China Hospital, Sichuan University, Chengdu, China.

出版信息

Gland Surg. 2021 Feb;10(2):826-831. doi: 10.21037/gs-21-40.

DOI:10.21037/gs-21-40
PMID:33708564
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7944058/
Abstract

This paper presents a case study of a 78-year-old male patient who presented with exacerbated skin redness and edema on the left chest wall, especially on the left breast, and who had been suffering from associated pruritus for 6 months. The patient also presented with enlarged ipsilateral axillary lymph nodes that were suspected to be carcinomas after a preliminary ultrasound and enhanced computerized tomography (CT) examination were performed. To examine these symptoms, an ultrasound-guided core biopsy and a chronic inflammatory test were also performed. The results of the excision biopsy and the immunohistochemistry test of the left breast and ipsilateral lymph node revealed no signs of cancer in this patient. Finally, combined with his medical history, the laboratory tests and pathology results, the patient was diagnosed with plasma cell mastitis (PCM) after another suspicious lesion (e.g., inflammatory breast cancer, etc.) was excluded. PCM is a kind of benign lesion of the breast with an unclear etiology. It usually affects non-pregnant and non-lactational females, who display clinical symptoms that are often similar to those of inflammatory breast cancer (IBC), the main manifestations were erythema and edema on the chest wall. To date, there is no standardized clinical treatment strategy or management approach for PCM.

摘要

本文介绍了一例78岁男性患者的病例研究。该患者左胸壁,尤其是左侧乳房出现皮肤发红和水肿加剧的症状,并伴有6个月的瘙痒。患者同侧腋窝淋巴结肿大,在进行初步超声和增强计算机断层扫描(CT)检查后怀疑为癌。为检查这些症状,还进行了超声引导下的粗针活检和慢性炎症检测。左乳房和同侧淋巴结的切除活检及免疫组化检测结果显示该患者无癌症迹象。最后,结合其病史、实验室检查和病理结果,在排除其他可疑病变(如炎性乳腺癌等)后,该患者被诊断为浆细胞性乳腺炎(PCM)。PCM是一种病因不明的乳腺良性病变。它通常影响非妊娠和非哺乳期女性,其临床症状常与炎性乳腺癌(IBC)相似,主要表现为胸壁红斑和水肿。迄今为止,对于PCM尚无标准化的临床治疗策略或管理方法。

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Clinical efficacy of fiberoptic ductoscopy in combination with ultrasound-guided minimally invasive surgery in treatment of plasma cell mastitis.纤维乳管镜联合超声引导下微创手术治疗浆细胞性乳腺炎的临床疗效
Clin Exp Obstet Gynecol. 2016;43(5):742-746.
2
Activation of the IL-6/JAK2/STAT3 pathway induces plasma cell mastitis in mice.IL-6/JAK2/STAT3 通路的激活可诱导小鼠浆细胞性乳腺炎。
Cytokine. 2018 Oct;110:150-158. doi: 10.1016/j.cyto.2018.05.002. Epub 2018 May 9.
3
IgG4-Related Sclerosing Disease of the Breast in a Male Patient.男性患者的乳腺IgG4相关性硬化性疾病
Int J Surg Pathol. 2017 Dec;25(8):711-715. doi: 10.1177/1066896917714324. Epub 2017 Jun 14.
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Inflammatory breast cancer: a proposed conceptual shift in the UICC-AJCC TNM staging system.炎性乳腺癌:国际抗癌联盟(UICC)-美国癌症联合委员会(AJCC)TNM分期系统中提议的概念转变
Lancet Oncol. 2017 Apr;18(4):e228-e232. doi: 10.1016/S1470-2045(17)30192-4.
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Plasma Cell Mastitis in Men: A Single-center Experience and Review of the Literature.男性浆细胞性乳腺炎:单中心经验及文献综述
In Vivo. 2016;30(6):727-732. doi: 10.21873/invivo.10987.
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Plasma cell mastitis in women with rheumatoid arthritis treated with TNFα antagonists: Report of 2 cases.用肿瘤坏死因子α拮抗剂治疗的类风湿关节炎女性患者的浆细胞性乳腺炎:2例报告
Joint Bone Spine. 2016 Oct;83(5):593-4. doi: 10.1016/j.jbspin.2015.12.001. Epub 2016 Jan 13.
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IL-6/STAT3 signaling pathway is activated in plasma cell mastitis.白细胞介素-6/信号转导及转录激活因子3信号通路在浆细胞性乳腺炎中被激活。
Int J Clin Exp Pathol. 2015 Oct 1;8(10):12541-8. eCollection 2015.
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