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2
Efficacy and safety of Viscum album extract (Helixor-M) to treat malignant pleural effusion in patients with lung cancer.槲寄生提取物(Helixor-M)治疗肺癌恶性胸腔积液的疗效和安全性。
Support Care Cancer. 2019 May;27(5):1945-1949. doi: 10.1007/s00520-018-4455-z. Epub 2018 Sep 14.
3
Surgical chylothorax in neonates: management and outcomes.新生儿外科乳糜胸:处理与结局。
World J Pediatr. 2018 Apr;14(2):110-115. doi: 10.1007/s12519-018-0134-x. Epub 2018 Mar 5.
4
Safety of intravenously applied mistletoe extract - results from a phase I dose escalation study in patients with advanced cancer.静脉注射槲寄生提取物的安全性——晚期癌症患者I期剂量递增研究结果
BMC Complement Altern Med. 2017 Sep 18;17(1):465. doi: 10.1186/s12906-017-1971-1.
5
Management of Chyle Leak after Head and Neck Surgery: Review of Current Treatment Strategies.头颈部手术后乳糜漏的管理:当前治疗策略综述
Int J Otolaryngol. 2017;2017:8362874. doi: 10.1155/2017/8362874. Epub 2017 Jan 19.
6
Embolization for Thoracic Duct Collateral Leakage in High-Output Chylothorax After Thoracic Surgery.胸腔手术后高输出量乳糜胸胸导管侧支渗漏的栓塞治疗
Cardiovasc Intervent Radiol. 2017 Jan;40(1):55-60. doi: 10.1007/s00270-016-1472-5. Epub 2016 Oct 14.
7
Thoracic duct lesions in thyroid surgery: An update on diagnosis, treatment and prevention based on a cohort study.甲状腺手术中的胸导管损伤:基于队列研究的诊断、治疗和预防更新。
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Chyle Fistula After Neck Dissection: An 8-Year, Single-Center, Prospective Study of Incidence, Clinical Features, and Treatment.颈部清扫术后乳糜瘘:一项为期8年的单中心发病率、临床特征及治疗的前瞻性研究
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提取(Helixor-M)治疗改良根治性颈清扫术后胸导管损伤:病例报告

extract (Helixor-M) treatment for thoracic duct injury after modified radical neck dissection: a case report.

作者信息

Kim Chai-Won, Kim Jeong-Soo, Lee Ae-Hee, Kim Yong-Seok

机构信息

Department of Surgery, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea. 271, Cheonbo-ro, Uijeongbu-si, Gyenggi-do, Republic of Korea.

Department of Surgery, Seoul St. Mary's Hospital, college of Medicine, The Catholic University of Korea. 222, Banpo-daero, Seocho-gu, Seoul, Republic of Korea.

出版信息

Gland Surg. 2021 Feb;10(2):832-836. doi: 10.21037/gs-20-629.

DOI:10.21037/gs-20-629
PMID:33708565
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7944075/
Abstract

Chyle leakage after modified radical neck dissection is a rare condition that could be occasionally life-threatening if untreated. We report the first case of successful management of a thoracic duct injury using extract (Helixor-M). A 54-year-old woman diagnosed with papillary thyroid cancer of the right lobe of the thyroid with metastasis to cervical lymph node levels II-VI, bilaterally, underwent total thyroidectomy and modified radical neck dissection. Three days postoperatively, the surgical team identified a thoracic duct injury due to drainage of chyle from the Jackson-Pratt drain inserted in the right side of the patient`s neck. Various medical treatments (octreotide, withdrawal of enteral feeding, and total parenteral nutrition) and surgical treatments [lymphatic ligation of cervical lymph node level IV and negative pressure wound therapy (vacuum-assisted closure)] were performed, but the drainage persisted. extract (Helixor-M) was then injected through the drain. The dose of extract was increased while being cautious of its adverse effects, such as nausea, vomiting, erythema, induration at the injection site, and flu-like symptoms. The injection was effective in stopping the drainage and the patient's condition improved, without recurrence. The patient was discharged on the 64 postoperative day without any further complications. Our results suggest that treatment of thoracic duct injury after neck surgery with extract (Helixor-M) may be a novel, less invasive alternative approach to treat cases resistant to standard treatments.

摘要

改良根治性颈清扫术后乳糜漏是一种罕见的情况,如果不治疗偶尔可能危及生命。我们报告首例使用提取物(Helixor-M)成功处理胸导管损伤的病例。一名54岁女性被诊断为右叶甲状腺乳头状癌,双侧颈部Ⅱ-Ⅵ区淋巴结转移,接受了全甲状腺切除术和改良根治性颈清扫术。术后三天,手术团队因患者颈部右侧插入的Jackson-Pratt引流管引出乳糜而发现胸导管损伤。进行了各种内科治疗(奥曲肽、停止肠内喂养和全胃肠外营养)和外科治疗[颈Ⅳ区淋巴结淋巴管结扎术和负压伤口治疗(真空辅助闭合)],但引流持续存在。然后通过引流管注射提取物(Helixor-M)。在谨慎注意其不良反应(如恶心、呕吐、红斑、注射部位硬结和流感样症状)的同时增加提取物的剂量。注射有效地停止了引流,患者病情改善,无复发。患者术后第64天出院,无任何进一步并发症。我们的结果表明,用提取物(Helixor-M)治疗颈部手术后的胸导管损伤可能是一种治疗对标准治疗耐药病例的新的、侵入性较小的替代方法。