Mirza Farhan A, Mitha Rida, Shamim Muhammad Shahzad
Department of Neurosurgery, The Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Department of Neurosurgery, Kentucky Neuroscience Institute, University of Kentucky, Lexington, KY, USA.
Asian J Neurosurg. 2020 Dec 21;15(4):800-808. doi: 10.4103/ajns.AJNS_185_20. eCollection 2020 Oct-Dec.
Laser interstitial thermal therapy (LITT) is gaining popularity in the treatment of both primary and secondary intracranial tumors. The goal of LITT is to deliver thermal energy in a predictable, controlled, and minimally invasive fashion. It can be particularly valuable in patients with recurrent tumors who, due to previous radiation or surgery, may have a potentially higher risk of wound breakdown or infection with repeat craniotomy. Deep-seated lesions that are often inaccessible through open approaches (thalamus, hypothalamus, mesial basal temporal lobe, brainstem) may also be suitable targets. The experience and data published thus far on this modality is limited but growing. This review highlights the use of LITT as a primary treatment method in a variety of intracranial tumors, as well as its application as an adjunct to established surgical techniques.
激光间质热疗（LITT）在原发性和继发性颅内肿瘤的治疗中越来越受欢迎。LITT的目标是以可预测、可控且微创的方式传递热能。对于复发性肿瘤患者，由于先前接受过放疗或手术，再次开颅手术时伤口破裂或感染的风险可能更高，LITT在这类患者中可能特别有价值。通过开放手术常难以触及的深部病变（丘脑、下丘脑、颞叶内侧基底、脑干）也可能是合适的靶点。迄今为止，关于这种治疗方式发表的经验和数据有限，但正在不断增加。本综述重点介绍了LITT作为多种颅内肿瘤的主要治疗方法的应用，以及其作为既定手术技术辅助手段的应用。
