Li Lei, Pang Xin, Liu Gang
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China.
ACS Biomater Sci Eng. 2018 Jun 11;4(6):1928-1941. doi: 10.1021/acsbiomaterials.7b00648. Epub 2017 Nov 15.
Early diagnosis and efficient therapy are very important for cancer management. Among the various intelligent delivery systems, near-infrared (NIR) light-triggered polymeric nanomicelles (PNMs) have emerged as a promising approach for imaging and photoactive delivery. This platform can be used for spatially and temporally controlled remote release of therapeutic payload molecules under NIR light irradiation. This review discusses the design and characteristics of PNMs as well as their recent application in imaging, drug delivery, and theranostics in photothermal and photodynamic therapy. The challenges and potential of PNMs in biomedical applications are also highlighted.
早期诊断和有效治疗对于癌症管理非常重要。在各种智能递送系统中，近红外（NIR）光触发的聚合物纳米胶束（PNM）已成为一种有前景的成像和光活性递送方法。该平台可用于在近红外光照射下对治疗性负载分子进行空间和时间控制的远程释放。本文综述了PNM的设计和特性，以及它们最近在光热和光动力疗法的成像、药物递送和诊疗中的应用。还强调了PNM在生物医学应用中的挑战和潜力。
