Harper M C
Department of Orthopaedics and Rehabilitation, Vanderbilt University, Nashville, Tennessee 37232.
Clin Orthop Relat Res. 1988 Jun(231):272-6.
The higher homologues of the alkyl-2-cyanoacrylates appear to possess properties useful for an osseous adhesive. Considering currently available bonding strengths, the most reasonable potential application of an osseous adhesive would appear to involve the stabilization of relatively small osteochondral fragments. If used as a means of temporary internal fixation, such an adhesive would need to be used in limited amounts in limited areas to allow for normal healing processes to occur between areas of adhesive placement. An animal study was therefore conducted utilizing the viscous isoamyl-2-cyanoacrylate monomer to evaluate its ability to maintain the reduction of an unstable osteochondral fragment while allowing for healing around the sites of adhesive placement. Used in limited quantities, this monomer appeared to allow adjacent healing to occur unimpeded and to be nontoxic to adjacent viable bone and cartilage. This adhesive also appeared to lend significant stability to the reduction of an osteochondral fragment in the knees of a series of rabbits.
烷基-2-氰基丙烯酸酯的高级同系物似乎具有对骨粘合剂有用的特性。考虑到目前可用的粘结强度，骨粘合剂最合理的潜在应用似乎涉及相对较小的骨软骨碎片的固定。如果用作临时内固定手段，这种粘合剂需要在有限的区域内少量使用，以便在粘合剂放置区域之间发生正常的愈合过程。因此，进行了一项动物研究，使用粘性异戊基-2-氰基丙烯酸酯单体来评估其在允许粘合剂放置部位周围愈合的同时保持不稳定骨软骨碎片复位的能力。以有限的量使用时，这种单体似乎能使相邻部位不受阻碍地愈合，并且对相邻的活骨和软骨无毒。这种粘合剂似乎也为一系列兔子膝盖处的骨软骨碎片复位提供了显著的稳定性。
