Gholami Behnood, Haddad Wassim M, Bailey James M, Muir William W
Autonomous Healthcare, Inc., Hoboken, NJ, United States.
School of Aerospace Engineering, Georgia Institute of Technology, Atlanta, GA, United States.
Front Vet Sci. 2021 Feb 23;8:642440. doi: 10.3389/fvets.2021.642440. eCollection 2021.
Fluid therapy is extensively used to treat traumatized patients as well as patients during surgery. The fluid therapy process is complex due to interpatient variability in response to therapy as well as other complicating factors such as comorbidities and general anesthesia. These complexities can result in under- or over-resuscitation. Given the complexity of the fluid management process as well as the increased capabilities in hemodynamic monitoring, closed-loop fluid management can reduce the workload of the overworked clinician while ensuring specific constraints on hemodynamic endpoints are met with higher accuracy. The goal of this paper is to provide an overview of closed-loop control systems for fluid management and highlight several key steps in transitioning such a technology from bench to the bedside.
液体疗法广泛应用于创伤患者以及手术中的患者。由于患者对治疗的反应存在个体差异，以及存在合并症和全身麻醉等其他复杂因素，液体治疗过程较为复杂。这些复杂性可能导致复苏不足或过度。鉴于液体管理过程的复杂性以及血流动力学监测能力的提高，闭环液体管理可以减轻劳累过度的临床医生的工作量，同时确保更准确地满足对血流动力学终点的特定限制。本文的目的是概述用于液体管理的闭环控制系统，并强调将此类技术从实验室转化到临床应用的几个关键步骤。
