三种不同造影剂（钆贝葡胺、钆喷酸葡胺和钆双胺）对臂丛神经磁共振成像的影响。

The effects of three different contrast agents (Gd-BOPTA, Gd-DTPA, and Gd-DOTA) on brachial plexus magnetic resonance imaging.

作者信息

Zhang Xiaojing, Wang Wensheng, Liu Tiefang, Qi Yeqing, Ma Lin

机构信息

Medical School of Chinese People's Liberation Army, Beijing, China.

Department of Radiology, The First Medical Centre, Chinese People's Liberation Army General Hospital, Beijing, China.

出版信息

Ann Transl Med. 2021 Feb;9(4):344. doi: 10.21037/atm-21-348.

DOI:10.21037/atm-21-348

PMID:33708971

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7944290/

Abstract

BACKGROUND

MRI is very important for guiding the diagnosis and treatment of brachial plexus diseases. The most used type of MRI brachial plexus imaging is the 3D Short Term Inversion Recovery (STIR) sequence with contrast agent. This study aimed to investigate the effect of three contrast agents; gadobenate dimeglumine (Gd-BOPTA), gadopentetate dimeglumine (Gd-DTPA), and Gadoteric Acid Meglumine (Gd-DOTA) on brachial plexus magnetic resonance imaging (MRI).

METHODS

We recruited 60 patients with suspected brachial plexus injury randomly into three groups. MRI images were obtained from each patient. Prior to scanning, the first group was injected with GD-BOPTA, the second group with Gd-DTPA, and the third with Gd-DOTA. The amount of contrast agent was 0.1 mmol/kg according to the weight of each patient, the injection rate was 1.5 mL/s, and 20 mL saline was injected at the same rate with a high-pressure injector. Immediately after the injection of contrast agent and saline, a 3D Sampling perfection with application optimized contrasts using different flip angle evolutions (SPACE) STIR sequence was used for scanning. The Signal Intensity (SI) and Standard Deviation (SD) of Maximal intensity projection (MIP) images for regions outside the anatomy (ROI background) with area of 17 mm on both sides of the C6 peripheral nerves (ROI nerve), and tissue adjacent to the peripheral nerves (ROI tissue) were obtained. Signal to noise ratio (SNR) and contrast to noise ratio (CNR) were then calculated.

RESULTS

The SNR was 40.66±25.27, 34.65±14.86, and 44.63±30.79 for Gd-BOPTA, Gd-DTPA, and Gd-DOTA, respectively and the CNR was 20.24±15.17, 16.07±7.50, and 20.84±15.53 for Gd-BOPTA, Gd-DTPA, and Gd-DOTA, respectively. In addition, there was no statistical difference in the SNR or CNR of brachial plexus nerves using the three contrast agents to enhance the 3D SPACE sequence χ=1.877, P=0.391>0.05 and χ=1.717, P=0.424, respectively.

CONCLUSIONS

There were no significant differences in the efficacy of three contrast agents in imaging the brachial plexus.

摘要

背景

磁共振成像（MRI）对于臂丛神经疾病的诊断和治疗指导非常重要。MRI臂丛神经成像最常用的类型是使用造影剂的三维短反转恢复（STIR）序列。本研究旨在探讨三种造影剂钆布醇（Gd-BOPTA）、钆喷酸葡胺（Gd-DTPA）和钆特酸葡甲胺（Gd-DOTA）对臂丛神经磁共振成像（MRI）的影响。

方法

我们将60例疑似臂丛神经损伤的患者随机分为三组。获取每位患者的MRI图像。扫描前，第一组注射Gd-BOPTA，第二组注射Gd-DTPA，第三组注射Gd-DOTA。根据每位患者的体重，造影剂用量为0.1 mmol/kg，注射速率为1.5 mL/s，并用高压注射器以相同速率注射20 mL生理盐水。在注射造影剂和生理盐水后立即使用三维不同翻转角演化的采样完美应用优化对比度（SPACE）STIR序列进行扫描。获取C6周围神经两侧面积为17 mm的解剖区域外（感兴趣区背景）、周围神经（感兴趣区神经）和周围神经相邻组织（感兴趣区组织）的最大强度投影（MIP）图像的信号强度（SI）和标准差（SD）。然后计算信噪比（SNR）和对比噪声比（CNR）。

结果

Gd-BOPTA、Gd-DTPA和Gd-DOTA的SNR分别为40.66±25.27、34.65±14.86和44.63±30.79，Gd-BOPTA、Gd-DTPA和Gd-DOTA的CNR分别为20.24±15.17、16.07±7.50和20.84±15.53。此外，使用三种造影剂增强三维SPACE序列时，臂丛神经的SNR或CNR无统计学差异，χ=1.877，P=0.391>0.05和χ=1.717，P=0.424。